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4CPS-234 Pharmaceutical interventions in the emergency department: relevance in high-alert medications
  1. C Caballero Requejo1,
  2. M Onteniente Candela1,
  3. P Salmerón Ruiz2,
  4. M Gil Candel1,
  5. I Salar Valverde1,
  6. C Gallego Muñoz1,
  7. E Urbieta Sanz1
  1. 1Hospital Universitario Reina Sofia, Pharmacy Department, Murcia, Spain
  2. 2Hospital Universitario Reina Sofia, Emergency Department, Murcia, Spain


Background The Institute for Safe Medication Practices (ISMP) defines high-alert medications (HAM) as drugs that bear a heightened risk of causing significant patient harm when used in error. Medication errors are frequent in the hospital Emergency Department (ED), and the most common drugs involved in these errors are HAM.

Purpose To assess the potential impact of the pharmaceutical interventions (PIs) on HAM in patients at the ED observation unit (EDOU).

Material and methods Prospective observational study, conducted from July to September of 2017 in the EDOU of a referral hospital, which has a mean of admissions of 20 patients/day. The pharmacist performed clinical activity in the ED from Monday to Friday in the morning. Variables included in the analysis were: sex, age, admission diagnosis classified with International Classification of Diseases, Ninth Revision, Clinical Modification(ICD-9-CM), number and type of PIs, value of potential impact of PIs (Overhage et al.1) and classification of ISMP list of HAM. Analysis was performed using SPSS Statistics IBP-19 version.

Results In the study period, 579 patients were in the EDOU during the working hours of the pharmacist, who intervened in 120 patients (20.7%). 52.5% were males and mean age was 70.84±15.5 years. The most frequent admission diagnosis in patients with PIs were: chest pain 11.7%, acute respiratory failure 7.5%, intermediate coronary syndrome 6.7%, urinary tract infection 3.3%, congestive heart failure 3.3%, sepsis 2.5%, hyposmolality and/or hiponatremia 2.5% and haemorrhage of gastrointestinal tract 2.5%.

Two hundred and thirty-seven PIs were performed (1.97±1.6/per patient). The most frequent types of PIs were: start chronic treatment 41.8%, modify dose 9.7%, therapeutic equivalent 8.4%, discontinue chronic treatment 7.6%, start acute pathology treatment 5.9%, adjustment for renal failure 5.5, and allergy 5.5%. 75.5% of PIs were made in chronic treatment, and 24.5% in acute patology. 71.3% of PIs had a potential impact on patient care, and 37.6% were made on HAM. The relevance of PIs in HAM was higher than in the rest of the medication, being statistically significant (p<0.001).

Conclusion Pharmacists at the ED had a positive impact on the medication process, improving the safety and effectiveness of prescriptions, and minimising the risk to the patient, especially with HAM.

Reference and/or Acknowledgements 1. Overhage JM, et al. Practical, reliable, comprehensive method for characterising pharmacists’clinical activities. Am J Health Syst Pharm1999Dec 1;56(23):2444–50.

No conflict of interest

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