Article Text

Download PDFPDF
5PSQ-037 Evolution of the antimicrobial stewardship programme quality indicators in a third-level hospital
  1. MC Conde García1,
  2. JR Barbera Farre2,
  3. R Carranza Gonzalez3,
  4. C Notario Dongil1,
  5. JC Valenzuela Gamez1,
  6. B Proy Vega1,
  7. JA Garcia Quiñones2
  1. 1H. G. la Mancha Centro, Pharmacy, Alcazar de San Juan, Spain
  2. 2H. G. la Mancha Centro, Internal Medicine, Alcazar de San Juan, Spain
  3. 3H. G. la Mancha Centro, Microbiology, Alcazar de San Juan, Spain


Background Our antimicrobial stewardship programme was introduced in 2016 in the quality certification system of our hospital and different indicators were designed to evaluate the quality of the process, establishing a limit of acceptability (LA) for each of them.

Purpose The objective of this study is to determine the indicators from January 2016 to June 2017 and to analyse if they are within the established limit.

Material and methods Indicators have been analysed semiannually except antimicrobial resistance that has been determined annually. Indicators and LA for each case are:

  • Antimicrobial consumption: DDD/1000 stays (LA=100).

  • Toxicity: carbapenem neurotoxicity (LA=2%) and clostridium difficile isolates (LA=5%).

  • Clinical results: mortality in patients with bacteraemia, both global (LA=20%) and attributable to bacteraemia (LA=10%).

  • Resistance to antimicrobials: variation from the previous year (LA=5%).

Results Results obtained for each of the indicators in the first and second half of 2016 and the first half of 2017 are:

  • DDD/1000 stays: 77.92 and 65.7

  • Neurotoxicity: None, 0.5% and 0.17%.

  • Clostridium difficile: 0.5%, 0.4% and 0.34%.

  • Global mortality in patients with bacteraemia: 10%, 17% and 14%.

  • Mortality attributable to bacteraemia: 5%, 3.6% and 10%.

  • Resistances: a slight improvement in enterobacteria susceptibility is observed, while in P. aeruginosa there is an upward tendency of resistance, especially to carbapenems and ciprofloxacin. For Gram + bacteria, the sensitivity in S. aureus and E. faecalis increases, but also the resistance to ampicillin in E. faecium. The cumulative nosocomial incidence of ESBL–E. coli and P. aeruginosa resistant to carbapenemics has remained stable and has increased in ESBL–K. pneumoniae, carbapenemase producing enterobacteria and extremely resistant enterobacteria.

The acceptability limits have been fulfilled in all cases except for K. pneumoniae and P. aeruginosa resistances.

Conclusion It is essential to establish indicators to evaluate the quality of the processes to analyse their evolution in detecting problems and design improvement strategies. Our revision shows that all parameters analysed are within the limit of acceptability except some resistance data for Gram – bacteria, mainly due to the appearance in our hospital of an outbreak of extremely resistant K. pneumoniae and the appearance of carbapenemases. The impact on the resistances is expected to be obtained later.

No conflict of interest

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.