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5PSQ-084 Safety and effectiveness of switching to infliximab biosimilar in digestive and rheumatological pathology
  1. J Ramos Rodríguez
  1. Hospital Universitario de Canarias, Pharmacy, Santa Cruz de Tenerife, Spain


Background The introduction of biosimilar drugs into clinical practice allows us to maintain the effectiveness and safety of treatments, taking greater advantage of health resources

Purpose The objective of the study was to evaluate the safety and effectiviness of infliximab biosimilar (IFXb) in patients previously treated with original infliximab (IFXo) in digestive and rheumatology pathology in a third-level hospital.

Second, we calculated the savings that this measure has made.

Material and methods A retrospective, 11 month retrospective study (April 2016 to March 2017) in which all patients treated with IFXo were switched to IFXb.

The following variables were recorded: sex, age, pathology, weeks of treatment with IFXo, weeks of treatment with IFXb, dose increases of IFXb, decreased dose interval, increased dose of immunomodulatory drugs, change of treatment and reactions to adverse effects. Data were obtained from the medical records using the computer application SAP.

Results A total of 48 patients were switched to IFXb. 38 patients had Crohn’s disease, eight ulcerative colitis, one ankylosing spondylitis and one rheumatoid arthritis.

The change to IFXb was only performed in those situations where a stabilisation of the disease had been achieved in a sustained manner.

Only one patient required treatment intensification and a total of four patients required an increased dose of immunomodulatory drugs.

Adverse reactions of interest different from those usually described with IFXo were not identified.

The cost per IFXo vial (100 mg) was €357 while IFXo (100 mg) cost €251. The total amount spent until the change to IFXb was €1,562,400.

If all patients had been treated with IFXo, the cost would be €2 22 084. The real cost of the change to iFXb was €149,847, so the estimated saving with this measure was €72 237 (33%)

Currently, the change to IFXb has been made in 68 patients.

Conclusion The data shown leads to increasing evidence that guarantees the switch in a safe way for patients. These types of measures also prove to be efficient due to the lower cost of biosimilars.

References and/or Acknowledgements 1. Danese S, Gomollon F. ECCO position statement: the use of biosimilar medicines in the treatment of Inflammatory Bowel Disease (IBD). Journal of Crohn’s and Colitis2013;7:586–9.

No conflict of interest

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