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5PSQ-123 Analysis of pharmacotherapeutic interventions carried out on patients allergic to medicines
  1. E Conesa Nicolás,
  2. MC González Pérez-Crespo,
  3. B Fernández-Lobato,
  4. IG Pérez Pérez,
  5. LM Escondrillas Gómez,
  6. MC Mira Sirvent,
  7. I Muñoz García,
  8. AC Viney,
  9. S Nuñez Bracamonte,
  10. A Lloret Llorca,
  11. CJuez Santamaría
  1. Hospital General Universitario Santa Lucía, Servicio de Farmacia, Cartagena, Spain


Background Pharmacotherapeutic interventions (PI) for allergy to medicines allows for an increase in the patient’s safety and the patient’s quality of care.

Purpose Analysis of the PI for allergy to medicines carried out on patients who are in a tertiary hospital.

Material and methods Retrospective descriptive study carried out during January, February and March 2017.

A database was designed where patients who had been subjected to a PI for allergy to medicines were gathered together. The following variables were established: age, sex, pharmacotherapeutic group or medicine to which the patient was allergic, reports and valuation from the Allergy Service (AS), PI carried out and also agreement or not on the part of the doctor responsible for the patient.

Results One hundrd and three patients were identified with PI for allergy to medicines, 37 of which were males. The average age was 66%±19.35. 75.78% (n=78) patients were allergic to non-steroid antiinflammatories, 11.65% (n=12) to betalactam antibiotics, 4.85% (n=5) to sulphamides, 2.91% (n=3) to fluourquinalones, 0.97% (n=1) to corticoids and 3.88% (n=4) were lactose-intolerant. 7.77%( n=8) patients had been prescribed the medicine to which they were allergic. In 92.23% (n=95) patients the prescribed medicine was from the same therapeutic group and/or there was the possibility of crossed hyper-sensitivity reactions.

In 83.49% (n=86) patients the allergy had not been studied by the AS. In 8.74% (n=9) cases the allergy was confirmed, in 2.91% (n=3) cases it was discarded and 4.85% (n=5) patients continued the study.

74.76% (n=77) of the interventions were accepted by the doctor. In 18.45% (n=19) cases the prescribed medicine was suspended. In the rest the doctor confirmed tolerance to the medicine. 25.24% (n=26) of the interventions were not accepted.

Conclusion The number of PI for allergy to medicines was high, in spite of the fact that the allergy was indicated in alerts of the programme of clinical histories Selene®. In the majority of cases the allergy was not studied by the AS which supposes that many patients did not receive treatment that could have benefited them.

The elaboration of an informative bulletin about allergies to medicines by the pharmaceutical service, directed at medical and nursing staff could be a useful tool for identifying possible allergies to medicines and crossed hypersensitivity reactions, increasing the safety of the patient.

No conflict of interest

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