Background Inappropriate prescription of antimicrobials has a significant epidemiological impact, since it favours the selection of strains of resistant microorganisms.

Purpose Evaluate the changes in antimicrobials or route of administration by the infectious diseases team in a third-level hospital according to a local programme.

Material and methods Observational and retrospective study. Every Monday during the study period (January to March 2017) all those patients selected by a pharmacist who meet the following inclusion criteria were: 1. Prescription of IV quinolones for more than three days. 2. Prescription of carbapenems, daptomycin, linezolid, cefepime, tigecycline and echinocandins for more than 5 days. On days 3 and 5, his doctor was informed by a reading alarm in the prescription programme of the possibility of switching quinolone to the oral route or the convenience of using these restricted antimicrobials, respectively. In the case of persistence on days 5 and 7, the pharmacist sent a semanal e-mail to a member of the infectious diseases unit (IDU) concerning the need for maintenance or not of the intravenous route, and the need to continue or not with these restricted antimicrobials, respectively. The member of the IDU decided whether the quinolone was switched from the intravenous route to the oral route or if the restricted antimicrobials were modified to others if it was considered appropriate.

Results The results are described in Table 1.

Conclusion The collaboration between the pharmacy unit and infectious diseases has allowed us to optimise the use of antimicrobials in our hospital. However, it is necessary to increase the awareness and training of doctors concerning the inadequate use of antimicrobials due to the risks involved and the unnecessary health costs.

References and/or Acknowledgements Infectious diseases unit.

Conflict of interest: Corporate-sponsored research or other substantive relationships: Janssen, Alexion, Novartis.