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Palliative analgesia with topical sevoflurane in cancer-related skin ulcers: a case report
  1. F Dámaso Fernández-Ginés1,
  2. Manuel Cortiñas-Sáenz2,
  3. Ana Navajas-Gómez de Aranda3,
  4. Maria del Carmen Navas-Martinez4,
  5. José Antonio Morales-Molina5,
  6. Francisco Sierra-García1,
  7. Héctor Mateo-Carrasco6
  1. 1 Pharmacy Department, Torrecárdenas Hospital, Almería, Spain
  2. 2 Torrecárdenas Hospital, Almería, Spain
  3. 3 Anaesthesiology and Critical Care Medicine Department, Torrecárdenas Hospital, Almería, Spain
  4. 4 Urology Department, Torrecárdenas Hospital, Almería, Spain
  5. 5 Pharmacy Department, Hospital of Poniente, Almería, Spain
  6. 6 Royal Marsden NHS Foundation Trust, London, UK
  1. Correspondence to F Dámaso Fernández-Ginés, Pharmacy Department, Torrecárdenas Hospital, Almería 04009, Spain; fdamaso.fernandez{at}


A Caucasian 39-year-old male patient with a poorly-differentiated infiltrating epidermoid penile carcinoma with urethral invasion was diagnosed. The patient received concomitant adjuvant chemotherapy with radiotherapy in the palliative setting, which produced painful ulceration of tumour lesions at loco-regional level (Numerical Rate Scale, NRS=9). The patient consented for treatment with direct topical sevoflurane instillations, at initial doses of 1 mL/cm2 of ulcerated area, as per unit protocol. The local use of undiluted sevoflurane achieved a marked reduction of the pain score in both nociceptive and irruptive pains (average NRS=3 immediately post-application). This improvement was corroborated by a decline in total morphine needs, any adverse events associated with major opiates. PGI-I and CGI-I scales were used before and after treatment with topical sevoflurane to assess patient and clinician perceptions of improvement in the quality of life. The pharmacy of our hospital had the responsibility to elaborate pre-loaded syringes with sevoflurane so that the patient was instilled simply and comfortably.

  • penile cancer
  • skin ulcer
  • palliative care
  • topical drug administration
  • sevoflurane
  • refractory pain

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