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4CPS-139 The piramid study: patients treated by myeloma oral medication have a bad compliance
  1. N Allaire,
  2. JF Huon,
  3. P Nizet,
  4. C Dubreuil,
  5. V Burgeot,
  6. I Rouiller,
  7. L Flet,
  8. M Tching-Sin
  1. CHU Nantes, Pharmacy, Nantes, France


Background Like other cancerous diseases, there are now many oral treatments for haematological malignancies. These oral products have a lot of advantages, but their effectiveness depends on patient compliance. Do they have a good effect?

Purpose This study aimed to assess patient medication compliance for myeloma oral treatments (Imids: Thalidomid, Lenalidomid, Pomalidomid) and to identify factors associated with medication compliance by adult outpatients.

Material and methods A cross-sectional prospective study was conducted at a university teaching hospital from January to August 2018.

Investigational medication compliance was assessed at the time of the renewal dispensation using the Morisky questionnaire. Other questionnaires were completed by outpatients at home: SF-36 quality of life, SATMED-Q satisfaction of treatment and HLQ health literacy. Demographic and other baseline data were collected using self-administered questionnaires.

Results Of the 62 participants, 36 (58.1%) were male, and the median age was 69 years (range: 43–85 years). The mean compliance Morisky score was 7.12/8% and 45.9% of the patients had a score of 8/8 (good observance). Patients were divided into two groups for the analysis: the good adherence one (score >7, n=28) and the medium/poor adherence group (score ≤7, n=33).

In univariate analysis, the Morisky medication compliance score was negatively correlated with existence of a tip to remember drug intake (p=0.0234), being a member of a patients’ association (p=0.0118) and positively correlated with treatment satisfaction (p=0.0081), perceived health (p=0.0175), a good psychic health (p=0.0119) and few limitations associated with it (p=0.0047).

Conclusion Only half the included outpatients had an optimal adherence of their medication. Having a poor satisfaction of their treatment and a poor psychic health were important risk factors for inadequate medication compliance.

This and other data suggest that hospitals and health professionals should encourage initiatives aimed at improving medication compliance in adults treated by Imids. Therapeutic education is not the easiest solution, due to the necessity of training. Pharmaceutic interviews could be easier to set up. To maximise the efficiency of these interventions, they should be aimed to poor compliance assumed patients.

References and/or acknowledgements No conflict of interest.

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