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4CPS-250 Influence of time and storage conditions in the stability of neonatal total parenteral nutrition admixtures
  1. L Otero Millan1,
  2. N Lago Rivero1,
  3. C Vazquez Lopez1,
  4. JL Legido Soto2,
  5. G Piñeiro Corrales1,
  6. A Blanco Rodicio3,
  7. M Alonso Iglesias1,
  8. S Lopez Gonzalez1,
  9. C Costas Carrera1,
  10. MC Pascual Rubin1,
  11. C Perez Rego1
  1. 1Hospital Álvaro Cunqueiro, Pharmacy, Vigo, Spain
  2. 2Universidad de Vigo, Física Aplicada, Vigo, Spain
  3. 3Hospital Álvaro Cunqueiro, Emergency, Vigo, Spain


Background Ternary mixtures in parenteral nutrition have a complex composition. Thus, interactions between those components can occur and lead to instability of the mixture, compromising its safety. It is possible that a process of destabilisation of the lipid emulsion starts due to aggregation of fat globules.

Purpose To analyse the stability and safety of neonatal total parenteral nutrition admixtures (TPN) as a function of globule size, time and storage conditions.

Material and methods We studied eight TPN compositions (100 ml) designed following the premature infants’ protocol in our hospital for TPN prescription and elaboration. All the samples were macronutrients (glucose, lipids and proteins) and micronutrients ternary mixtures, calculated according to the nutritional requirements of a 1 kg neonate during the first 8 days of life. The globule size was measured by laser diffraction (Beckman Coulter LS I3 320) on the preparation day (day 0) and after 7 days. The samples were stored at refrigerated and room temperature. They were prepared in duplicate. We used the SPSS v20 program to perform the statistical analysis.

Results The TPN1 and TPN2 have larger globule size, but the differences are not statistically significant (p=0.396) with respect to the rest of the samples.

No significant differences were observed between the globule size at day 0 and day 7 (p=0.520).

No significant differences were observed between the globule size of the samples according to the form of storage (p=0.225).

Abstract 4CPS-250 Table 1

Conclusion The preliminary results suggest that TPNs with lower lipid concentration have an increase in globule size. We will require confirmation by further experiments.

Our results in globule size demonstrate that TPNs are stable and safe during the study period and independently of the storage conditions.

References and/or acknowledgements No conflict of interest.

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