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5PSQ-002 Iatrogenic hypoglycaemia: frequency and impact on quality of life among type 2 diabetes mellitus patients
  1. K Ben Jeddou1,
  2. A Abbassi2,
  3. H Sakly1,
  4. E Ben Mrad2,
  5. K Khiari3,
  6. Z Ouahchi2
  1. 1University Hospital of Bizerte, Pharmacy, Bizerte, Tunisia
  2. 2University Hospital of Charles Nicolle, Pharmacy, Tunis, Tunisia
  3. 3University Hospital of Charles Nicolle, Internal Medicine, Tunis, Tunisia


Background Hypoglycaemia is the antidiabetic drugs’ major side effect, especially for insulin and insulin secretagogues. Few observations in real-life iatrogenic hypoglycaemia studies on type 2 diabetes have been carried out.

Purpose To assess iatrogenic hypoglycaemia frequency on type 2 diabetic patients and to measure its impact on quality of life.

Material and methods It was an observational cross-sectional study among type 2 diabetes inpatients and outpatients at the endocrinology department. Patients were asked the number of times they experienced light or moderate hypoglycaemia in the past 6 months and severe hypoglycaemia in the past 12 months. Quality of life related to patient’s health was measured by the Euro 5 quality of life dimensions (EQ-5D). The EQ-5D score index was determined through a conversion table. This score can range from −0.529 to 1 in our country. The EQ-5D also includes a visual analogue scale (EQ-VAS) graduated from 0 to 100. Statistical tests ANOVA and the Chi-square test 2 were applied and statistical significance was accepted at p<0.05

Results A total of 141 type 2 diabetic patients were enrolled. Average age was 59.3±10.2 years and the sex ratio was 0:64. Among patients, 71 (50.4%) reported at least one incident of hypoglycaemia. Only nine patients (6%) had immediately confirmed hypoglycaemia by a blood glucose finger less than 0.7 g/L. Seventeen patients (12%) reported severe hypoglycaemia, whereas hospitalisation was required for six cases in the emergency department, including treatment with glucagon or glucose solution. Median score of the EQ-VAS was 65. Severe hypoglycaemia occurrence was significantly related to mobility problems (p=0.027), autonomy (p=0.015) and usual activities (p=0.034). Hypoglycaemia is associated with a quality of life index less than the average level (p<0.001). Similar results were found in other studies. Hypoglycaemic events number had no significant impact on quality of life, with P-values greater than 0.05 for all EQ-5D dimensions.

Conclusion Our study revealed that iatrogenic hypoglycaemia had elevated rates and it impacts type 2 diabetic patients’ quality of life. This major side effect should have more consideration by practitioners for better diabetes management.

References and/or acknowledgements Green AJ. Diabetes Res Clin Pract 2012;96:313–8.

No conflict of interest.

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