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6ER-015 Impact on pain management after a single viscosupplementation intraarticular injection in patients with hip osteoarthritis who failed conventional treatment
  1. MDM Villanova Lopez1,
  2. M Nuñez-Nuñez2,
  3. M Murillo-Izquierdo3,
  4. ÁS Raquel2,
  5. J Donaire4,
  6. S Sandoval5,
  7. M Camean Fernandez5
  1. 1Hospital Hospiten Estepona, Traumatology, Estepona, Spain
  2. 2Hospital San Cecilio, Pharmacy, Granada, Spain
  3. 3Hospital Univeristario Virgen Macarena, Pharmacy, Seville, Spain
  4. 4Hospital La Linea, Traumatology, La Linea De La Concepcion, Spain
  5. 5Hospital Virgen Macarena, Pharmacy, Seville, Spain


Background Viscosupplementation intraarticular injection with hyaluronic acid (HA) and platelet-rich plasma (PRP) has been shown to improve pain management in osteoarthritis.

Purpose We sought to describe the impact on analgesic consumption and VAS score after a a single viscosupplementation intraarticular injection in patients with hip osteoarthritis.

Material and methods Randomised controlled trial to compare the clinical efficacy and safety of a single ultrasound-guided intraarticular injection with autologous PRP versus HA in hip osteoarthritis was performed with a 1 year follow-up (four visits: baseline, 1, 4, 24, 48 weeks). Variables studied included the reduction in: VAS score, analgesic drugs’ consumption in doses (defined as total daily-defined-doses and type categorised according to OMS scale: type I, II and III for opioids.

Results A total of 74 patiens were randomly assigned to two groups and received one single injection, PRP (38 patients), AH (36 patients). Table 1 shows reduction in analgesic drugs’ consumption per group of treatment.

Within the first month, a significant reduction was shown in VAS score for both treatment arms in respect to last visit: 4 (2–6) vs. 7 (5–8) in PRP and 4.5 (2–7) vs. 7 (5–8) in HA; p<0.01. The 42.8% and 35.7% improvement in the PRP and HA groups, respectively, decrease to 28.5% in visit 3 for both arms. Pain management decrease although safer a year of Follow-up baseline levels were not achieved and only 3/74 (4%) patients decided to go for surgery during the follow-up period. No adverse events were observed in any of the treatment groups.

Conclusion Viscosupplementation with a single intraarticular injection with HA and PRP seem to be a safe and effective treatment option in improving pain management in hip osteoarthritis, ensuring a delay in surgery. Although the PRP cohort presented better profiles, no significant differences were found with the HA cohort.

References and/or acknowledgements None.

No conflict of interest.

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