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4CPS-064 Evaluation of broad-spectrum beta-lactam prescriptions (except carbapenems) in the military hospital of instruction mohammed V rabat
  1. Y Moutaouakkil1,
  2. Y Tadlaoui2,
  3. Y Atbib2,
  4. B Adouani1,
  5. A Bennana2,
  6. Y Cherrah1,
  7. J Lamsaouri2,
  8. Y Bousliman1
  1. 1Pharmacy Pole-Military Hospital of Instruction Mohammed V Rabat, Department of Pharmacology – Toxicology- University Mohammed V- Faculty of Medicine and Pharmacy-, Rabat, Morocco
  2. 2Pharmacy Pole-Military Hospital of Instruction Mohammed V Rabat, Department of Pharmacy Clinic- University Mohammed V- Faculty of Medicine and Pharmacy-, Rabat, Morocco


Background The prescription of antibiotics has become one of the most critical acts in hospitals.1 This is related to the risk of misuse of these drugs and its impact on the development of bacterial resistance and antibiotic inefficiency.

Purpose We aimed to assess broad-spectrum beta-lactam prescriptions (except carbapenems) and the impact of controlled dispensing, antimicrobial management team and antibiotic treatment reassessment in 48–72 hours.

Material and methods This is a descriptive study, which took place on a given day in all hospital units and analysed curative antibiotic broad-spectrum beta-lactam prescriptions. The assessment focused on indication, dosing, combinations, revaluation in 48–72 hours and treatment duration.

Results One-hundred and three prescriptions were identified: amoxicillin (9.70%, n=10), amoxicillin-clavulanic acid (43.69%, n=45), ceftriaxone (33%, n=34), piperacillin-tazobactam (3.88%, n=4), Ceftazidime (7.76%, n=8), and Cefepime (1.94%, n=2). The compliance of the indication, dosage, combinations and re-evaluation at 48–72 hours was satisfactory, respectively 67.96% (n=70), 81.55% (n=84), 82.75% (24/29 associations) and 65.04% (n=67). The compliance of the treatment duration was only 43.68% (n=45). Controlled dispensing showed interest in total antibiotic treatment duration: 76.69% vs. 34.95% compliance for non-controlled dispensed beta-lactams (p=0.02).

Conclusion The prescription or not of broad-spectrum betalactamines is a multifactorial and complex act, but the compliance regarding the duration of treatment could be improved, in particular by a strengthening of the controls of prescriptions.

Reference and/or acknowledgements

  1. Didouh M, Cheikh A, Zerhouni MW, et al. Les déterminants de la prescription des antibiotiques à l’hôpital. Revue d’Épidémiol Santé Pub 2018;66:S153.

Reference and/or acknowledgementsNo conflict of interest.

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