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Rational application of vancomycin in patients with various pathological conditions
  1. Hua Xiao Zhou1,
  2. Xin Chen2,
  3. Lijuan Shen2,
  4. Shuping Cai2,
  5. Hong Jian Ji3
  1. 1 Department of Nephrology, Yancheng Third People's Hospital, Yancheng, China
  2. 2 Department of Nephrology, Affiliated Yancheng Hospital of Southeast University Medical College, Yancheng, China
  3. 3 School of Pharmacy, The Yancheng Third People's Hospital, Yancheng, China
  1. Correspondence to Dr Hong Jian Ji, School of Pharmacy, The Yancheng Third People's Hospital, 224001 Yancheng, China; hongjianji2006{at}

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We are very interested in studies published by Chu et al and Šíma et al.1 2 Briefly, the former studies reported that the steady-state trough concentration of vancomycin was mainly affected by age, and the latter proposed an easy-to-use dosing nomogram for vancomycin therapy initiation. Both studies provided clear patient characteristics, and their interesting outcomes garnered our attention.

In China, the overprescription of antibiotics has been particularly severe in the past few decades, and the results of the national bacterial resistance monitoring network of China's Health Planning Commission in 2015 revealed that bacterial resistance is extremely serious. To solve this problem, every year, China's Ministry of Public Health organises a special examination for the rational use of antibiotics and standardises the use of antibiotics at all levels of hospitals. Therefore, the rational use of antibiotics is critical. Vancomycin is a commonly used drug worldwide for the treatment of gram-positive …

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  • Contributors Xiaohua Zhou and Xin Chen planned the article, discussed content, and wrote and reviewed the article. Lijuan Shen and Shuping Cai discussed content. Hongjian Ji was involved in case collection and helped to write the article, Joe Barber Jr helped to write the English text of a draft of this manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.