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Two methods for therapeutic drug monitoring of voriconazole: act according to circumstances
  1. Hua Xiao Zhou1,
  2. Xin Chen2,
  3. Hong Jian Ji3
  1. 1 Department of Nephrology, Yancheng Third people's Hospital, Yancheng, Jiangsu, China
  2. 2 Department of Nephrology, Affiliated Yancheng Hospital of Southeast University Medical College, Yancheng, Jiangsu, China
  3. 3 School of Pharmacy, The Yancheng Third People's Hospital, Yancheng, Jiangsu, China
  1. Correspondence to Dr Hong Jian Ji, School of Pharmacy, The Yancheng Third People's Hospital, Yancheng 224001, China; hongjianji2006{at}

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In the recently published study by Blanco-Dorado et al, 1 the authors described two methods for determining plasma concentrations of voriconazole: high performance liquid chromatography (HPLC) and an ARK immunoassay. After correlation of the two methods and the concordance of the values was evaluated, it was noted that both methods could be implemented for therapeutic drug monitoring (TDM) of voriconazole to avoid hepatotoxicity and enable continued effective therapy for patients with invasive fungal infections. We strongly agree with the finding that the HPLC method was simple and fast, and …

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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.