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- drug analysis
- therapeutic drug monitoring
- clinical pharmacy
- general medicine (see internal medicine)
- health & safety
In the recently published study by Blanco-Dorado et al, 1 the authors described two methods for determining plasma concentrations of voriconazole: high performance liquid chromatography (HPLC) and an ARK immunoassay. After correlation of the two methods and the concordance of the values was evaluated, it was noted that both methods could be implemented for therapeutic drug monitoring (TDM) of voriconazole to avoid hepatotoxicity and enable continued effective therapy for patients with invasive fungal infections. We strongly agree with the finding that the HPLC method was simple and fast, and …
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; internally peer reviewed.