Article Text

Download PDFPDF
4CPS-029 Preliminary results of an antimicrobial stewardship programme in an oncology department
  1. C Castillo-Martin1,
  2. A Martínez-Suarez1,
  3. P Retamar-Gentil2,
  4. S Sandoval-Fernandez Del Castillo1,
  5. M Murillo-Izquierdo1
  1. 1Hospital Universitario Virgen Macarena, Pharmacy, Seville, Spain
  2. 2Hospital Universitario Virgen Macarena, Infectious Diseases, Seville, Spain


Background and importance Misuse of antibiotics has been related to the emergence of multidrug resistant microorganisms which are related to worse outcome in infected patients. Antimicrobial stewardship programmes (ASPs) have been shown to improve antimicrobial use.

Aim and objectives To describe the characteristics of antimicrobial prescriptions and analyse the impact of a specific ASP implemented in an oncology department.

Material and methods A before and after ASP intervention was implemented in an oncology department in a tertiary hospital. Pre-intervention prescription characteristics were analysed through repeated point prevalence surveys in the previous year. The intervention was initiated in February 2019 based on a weekly ward round where non-tax advice was given to the oncologists about their active antibiotic prescriptions. Prescription features, rate of adherence to local guidelines and type and acceptance of the recommendations given to stop or de-escalate were recorded.

Results A total of 62 and 73 prescriptions were included in the pre- and post-intervention periods. respectively. Table 1 describes the prescription characteristics in both periods. Adherence to local guidelines was 51% and 59% in the pre- and post-intervention periods, respectively (p=0.39).

Abstract 4CPS-029 Table 1

In the intervention period, 26% of prescriptions were stopped and 12% de-escalated. Acceptance was 99%.

Conclusion and relevance An ASP weekly intervention in the oncology department showed a slight increase in adherence to local antibiotic guidelines. Nevertheless, this improvement was not statistically significant due to the short follow-up period and small sample size. Further studies are required to corroborate this improvement.

References and/or acknowledgements No conflict of interest.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.