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Fighting on two fronts: drug–drug interactions in people living with HIV infected with SARS-CoV-2
  1. Melda Bahap1,
  2. Emre Kara1,
  3. Gulay Sain Guven2
  1. 1 Department of Clinical Pharmacy, Hacettepe University Faculty of Pharmacy, Ankara, Turkey
  2. 2 Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey
  1. Correspondence to Melda Bahap, Department of Clinical Pharmacy, Hacettepe University Faculty of Pharmacy, Ankara 06800, Turkey; melda_610{at}

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People living with HIV (PLWH) who have a normal CD4 T-cell count and suppressed viral load may not be at an increased risk for COVID-19. Nonetheless, the majority of PLWH have other chronic or acute multimorbidity, which increases their risk. Indeed, almost half of the PLWH in Europe are older than 50 years and have comorbidities. Drug–drug interactions are also prevalent in these individuals, and people with drug interactions have an increased risk of morbidity and mortality.1 It is highly recommended that treatment for COVID-19 in PLWH generally follow the same protocols as for patients without HIV.2

Cytochrome P450 (CYP450) enzymes and efflux proteins such as P-glycoprotein (P-gp) are likely to result in drug interactions. Antiretroviral drugs can be divided into three main groups …

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  • Contributors MB: investigation, writing original draft. EK: resources, writing original draft. GSG: writing, review and editing, supervision.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.