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- drug-related side effects and adverse reactions
- drug monitoring
- metabolic side effects of drugs and substances
- drug substitution
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was detected in Wuhan, China about 1 year ago and caused a pandemic that has been ongoing for about 10 months. Optimal antiviral therapy has not yet been established in the treatment of coronavirus disease 2019 (COVID-19) caused by this virus.
Remdesivir is one of the most commonly used antiviral drugs in the treatment of COVID-19 worldwide. Remdesivir, a prodrug, converts to its active phosphate form and inhibits RNA-dependent RNA polymerase that enables the replication of the SARS-CoV-2.1 In vitro studies have demonstrated that remdesivir is a substrate for the cytochrome P450 (CYP450) enzymes CYP3A4, CYP2D6 and CYP2C8, as well as …
Correction notice This article has been corrected since it first published. The provenance and peer review statement has been included.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.