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Factors associated with a reduction in the quality of life of patients with chronic hepatitis C treated by ledipasvir/sofosbuvir therapy
  1. Yuka Aimono1,
  2. Noriko Kohyama2,
  3. Toshiro Kamoshida3,
  4. Toshinori Yamamoto4,
  5. Mari Kogo2
  1. 1 Department of Pharmacy, Hitachi, Ltd, Hitachi General Hospital, Hitachi, Ibaraki, Japan
  2. 2 Division of Pharmacotherapeutics, Department of Clinical Pharmacy, School of Pharmacy, Showa University—Hatanodai Campus, Shinagawa-ku, Tokyo, Japan
  3. 3 Department of Medical Gastroenterology, Hitachi, Ltd, Hitachi General Hospital, Hitachi, Ibaraki, Japan
  4. 4 Showa University Medical Foundation, Shinagawa-ku, Tokyo, Japan
  1. Correspondence to Mrs Yuka Aimono, Department of Pharmacy, Hitachi, Ltd., Hitachi General Hospital, Hitachi, Ibaraki, Japan; yuka.aimono.cp{at}hitachi.com

Abstract

Objective We investigated factors associated with a reduction in the quality of life and their OR of patients with chronic hepatitis C who underwent ledipasvir/sofosbuvir therapy.

Methods The subjects were 141 outpatients who had undergone ledipasvir/sofosbuvir therapy under a diagnosis of genotype I chronic hepatitis C or Child-Pugh A compensated cirrhosis at Hitachi General Hospital. The patient background before ledipasvir/sofosbuvir therapy, laboratory data and the Chronic Liver Disease Questionnaire scores during ledipasvir/sofosbuvir therapy were investigated. The Chronic Liver Disease Questionnaire consists of 29 questions, and the mean value is calculated as the overall score through a 7-step assessment by patients. Using two divisions: a Chronic Liver Disease Questionnaire score of <7 (symptoms are present) and that of 7 (no symptoms), as objective variables, patients with a Chronic Liver Disease Questionnaire score of <7 were defined as having a reduced quality of life. Independent factors significantly associated with a reduction in the quality of life were extracted using logistic regression analysis.

Results Based on the multivariate analysis, an alanine aminotransferase level of ≥23 U/L (OR: 4.380, 95% CI: 1.394 to 13.756) was extracted as an independent factor associated with a reduction in the quality of life (p<0.05).

Conclusion An increase in the baseline level of alanine aminotransferase was found to play a role in the reduction in the quality of life of patients with chronic hepatitis C who had undergone ledipasvir/sofosbuvir therapy.

  • clinical pharmacy
  • quality in healthcare
  • risk management
  • hepatology
  • side effects of drugs

Data availability statement

All data relevant to the study are included in the article or uploaded as supplementary information.

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Data availability statement

All data relevant to the study are included in the article or uploaded as supplementary information.

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