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Cluster of differantiation 26 (CD26) plays an important role in chronic graft versus host disease (GVHD), psoriasis, diabetes, haematological and solid cancers. In addition, S1, the spike protein of Middle East respiratory syndrome coronavirus, has been shown to enter human host cells using CD26, also known as dipeptidyl peptidase-4 (DPP-4), as a functional receptor.1 In a molecular docking study, it was determined that the S1 domain of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein could potentially interact with CD26, an important immunoregulatory factor for hijacking and virulence.2
In a retrospective observational case-control study, 338 patients with type 2 diabetes …
Contributors All authors contributed equally to the writing of the letter.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.