Article Text

Download PDFPDF
Relationship between amikacin pharmacokinetics and biological parameters associated with organ dysfunction: a case series study of critically ill patients with intra-abdominal sepsis
  1. Bita Shahrami1,
  2. Aida Sefidani Forough2,
  3. Seyedeh Sana Khezrnia1,
  4. Farhad Najmeddin1,
  5. Amir Ahmad Arabzadeh3,
  6. Mohammad Reza Rouini4,
  7. Atabak Najafi5,
  8. Mojtaba Mojtahedzadeh1
  1. 1 Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, The Islamic Republic of Iran
  2. 2 School of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia
  3. 3 Department of Surgery, Ardabil University of Medical Sciences, Ardabil, The Islamic Republic of Iran
  4. 4 Department of Pharmaceutics, Tehran University of Medical Sciences, Tehran, The Islamic Republic of Iran
  5. 5 Department of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Tehran, The Islamic Republic of Iran
  1. Correspondence to Professor Mojtaba Mojtahedzadeh, Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, The Islamic Republic of Iran; mojtahed{at}sina.tums.ac.ir

Abstract

Objectives This study aimed to evaluate the relationship between amikacin pharmacokinetics and the biomarkers associated with organ dysfunction in critically ill patients with intra-abdominal sepsis.

Methods A case series involving critically ill patients with intra-abdominal sepsis who received an amikacin loading dose of 20–25 mg/kg intravenous infusion was studied. The 1-, 2-, 4-, 6- and 24-hour amikacin serum concentrations were measured to calculate the pharmacokinetic parameters. The Sequential Organ Failure Assessment (SOFA) score, white blood cells, neutrophil to lymphocyte ratio, platelet count, serum creatinine, creatinine clearance, bilirubin, partial pressure of oxygen to fraction of inspired oxygen ratio, serum albumin, procalcitonin, lactate level, erythrocyte sedimentation rate (ESR) and C-reactive protein were recorded. A linear regression analysis was performed to examine the relationship between the amikacin pharmacokinetics and the biological parameters.

Results Twenty-one patients were studied. A significant correlation was found between the volume of distribution and ESR (p<0.05, r=0.844). Moreover, drug clearance had a significant inverse correlation with serum lactate (p<0.05, r=−0.603). No other significant correlations were found.

Conclusions ESR and serum lactate were identified as useful predictors of amikacin pharmacokinetics in critically ill patients with intra-abdominal sepsis and may help guide the selection of appropriate empirical dosing.

  • pharmacokinetics
  • critical care
  • drug monitoring
  • pharmacology
  • emergency medicine

Data availability statement

All data relevant to the study are included in the article. Not applicable.

Statistics from Altmetric.com

Data availability statement

All data relevant to the study are included in the article. Not applicable.

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.