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Advanced ALK-positive lung cancer with lorlatinib versus crizotinib in Asian patients with brain metastases
  1. Hung Shih-Chang
  1. Nantou Hospital, Nantou, Taiwan
  1. Correspondence to Dr Hung Shih-Chang, Nantou Hospital, Nantou, Taiwan; shihchan{at}

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I read with interest the work by Shaw et al entitled ‘First-line lorlatinib or crizotinib in advanced ALK-positive lung cancer’. The findings of this study are very inspiring for lung cancer treatment in Asian patients, especially those with brain metastases.1 I note that lorlatinib was found to be a very important treatment option in progression-free survival and overall survival rate. The hazard ratios (HRs) favoured lorlatinib over crizotinib across all subgroups of patients. In online supplemental figure S1, the HR was 0.32 (95% CI 0.20 to 0.49) for lorlatinib compared with crizotinib in the group with non-brain metastases, whereas it was …

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