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  • Monoclonal antibodies for the early treatment of paediatric COVID-19 patients: a tangible contribution from hospital pharmacists in the lack of evidence

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Monoclonal antibodies for the early treatment of paediatric COVID-19 patients: a tangible contribution from hospital pharmacists in the lack of evidence
  1. Sabrina Trivellato1,
  2. Daniele Mengato1,
  3. Daniele Donà2,
  4. Marica De Pieri2,
  5. Francesca Venturini1
  1. 1 Hospital Pharmacy Department, Padua University Hospital, Padova, Italy
  2. 2 Department for Women's and Children's Health, Division of Pediatric Infectious Diseases, Padua University Hospital, Padova, Italy
  1. Correspondence to Dr Daniele Mengato, Hospital Pharmacy, Padua University Hospital, Padova 35121, Italy; daniele.mengato{at}gmail.com

https://doi.org/10.1136/ejhpharm-2022-003562

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    Unlike adults, most paediatric patients experience mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, showing favourable outcomes and extremely low hospitalisation rates.1 However, if we consider frail patients, the risk of developing a severe coronavirus disease (COVID-19) increases to even life-threatening clinical scenarios.2

    Due to their immunosuppressive status, transplant recipients and onco-haematological children represent a restricted but vulnerable cohort of patients exposed to high-risk outcomes.2

    Currently available therapies approved by the European Medicines Agency (EMA) for early stages of infection in patients at high risk of developing a severe form of the disease include neutralising monoclonal antibodies (mAbs) and antiviral agents. However, only mAbs have been currently approved for paediatric patients …

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    Footnotes

    • Contributors ST and DM wrote the paper and collected the necessary data. DD and MDP revised the paper. FV supervised the whole process and promoted the project.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.