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4CPS-230 Allogeneic haematopoietic cell transplantation in patients aged <60 years with acute myeloid leukemia
  1. R Tamayo Bermejo,
  2. C Ortega de la Cruz,
  3. JC Del Río Valencia,
  4. IM Muñoz Castillo
  1. Regional University Hospital of Malaga, Pharmacy Department, Málaga, Spain


Background and Importance Allogeneic haematopoietic cell transplantation (allo-HCT) is a potentially curative therapeutic modality for acute myeloid leukaemia (AML), but it still carries high morbidity and mortality; there are limited data regarding outcomes, so it is important to research its results, and the factors that influence them.

Aim and Objectives To assess the survival of allo-HCT in AML patients age <60 years, describe its characteristics, and identify factors that are related to the best outcomes.

Retrospective observational study. We included all patients with AML, aged <60 years, who underwent allo-HCT performed at our centre between 2016-2019.

We analysed their age, sex, cytogenetic risk group, disease status at the time of transplantation, Karnofsky performance status (KPS) score, comorbidity indexes (HCT-CI and EBMTscore), donor type, source, conditioning regimens, graft-versus-host disease (GVHD) prophylaxis, retransplantation, donor age, donor sex, CMV-mismatch, ABO-mismatch, development of GVHD, related hospitalisations, progression, and death.

Overall survival (OS) and progression-free survival (PFS) were analysed using Kaplan-Meier and Log-Rank test.

Thirty-seven patients were included. Mean age was 44.81 ± 12.26 [18-59] years. 64.9% were women. 51.4% intermediate-risk and 43.2% high-risk. 70.3% in first complete remission (CR). 91.9% patients had a KPS score over 90% at the time of transplantation. 54.1% HCT-CI between 0-2, 81.1% EBMT score ≤4. 64.8% related donor (43.2% HLA-identical and 21.6% haploidentical), 35.1% unrelated donor (21.6% HLA-identical, 10.8% HLA 9/10, and 2.7% HLA 8/10). 70.3% allogeneic peripheral blood stem cell transplantation. 64.9% reduced-intensity conditioning. 16.2% retransplantation. Most donors were men >30 years. 37.8% received post-transplantation treatment with cyclophosphamide, tacrolimus, and mycophenolate mofetil. 18.9% CMV-mismatch (patient pos/ donor neg), 56.8% ABO-compatible, 54.1% development chronic GVHD and 40.5% acute GVHD. 43.2% did not require related hospitalisation.

PFS at 12 months was 72% (95% CI, 55-84%), and 51% (95% CI, 34-66%) at 24 months. OS at 12 months was 78% (95% CI, 61-89%) and 62% (95% CI, 45-76%) at 24 months. Median PFS and OS were not reached. The median follow-up for PFS was 33 months [1-69] and 34 months [1-69] for OS.

PFS was significantly higher in patients in 1st CR, EBMTscore ≤4, and lower-risk.

Conclusion and Relevance Patients undergoing allo-HCT show encouraging survival, although more extended follow-up is required to define more accurately their prognosis.

Conflict of Interest No conflict of interest

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