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5PSQ-135 Has an antimicrobial stewardship programme had an impact on the antibiotic consumption?
  1. O Urbina1,2,
  2. JC Gainzarain2,3,
  3. A Canut2,4,
  4. J Portu2,3,
  5. Z Ortiz de Zárate2,3,
  6. E Sáez de Adana2,3,
  7. M Campos5,
  8. JJ García1,
  9. E Gómez1,
  10. MD Martinez1,
  11. C Martinez1
  1. 1Araba University Hospital, Pharmacy Department, Vitoria-Gasteiz, Spain
  2. 2Bioaraba, Infectious Diseases Research Group, Vitoria-Gasteiz, Spain
  3. 3Araba University Hospital, Infectious Diseases Department, Vitoria-Gasteiz, Spain
  4. 4Araba University Hospital, Microbiology Department, Vitoria-Gasteiz, Spain
  5. 5University of Murcia, Faculty of Computer Science, Murcia, Spain


Background and Importance The increasing use of antimicrobials and the global surge of antimicrobial resistance is a major public health concern.

Antimicrobial Stewardship Programmes (AMSP) are an important security strategy in hospitals because their implementation promotes an optimal use of antimicrobials, improving patient outcomes while decreasing the risk of adverse events as well as antimicrobial resistance.

Aim and Objectives To evaluate if an AMSP had an impact in the overall consumption of antibiotics, measured as number of defined daily doses per 100 stays (DDD/100 s), in an acute care hospital during the first year of implementation.

Material and Methods AMSP started in Araba University Hospital in October 2020.

The AMSP was conducted 3 days per week by a hospital pharmacist and an infectious disease specialist with the possibility of consulting a microbiologist by telephone .

An Antimicrobial Stewardship Programme Support System (AMSPSS) was used to alert of antibiotic prescriptions that need a revision. These alerts were previously designed by the AMSP team.

Antibiotic recommendations were made in the health electronic record or by telephone to the patient responsible doctor. They were registered in the AMSPSS as well.

We retrospectively analised interventions and measured the global antibiotic consumption as DDD/100s using the pharmacy dispensation registers from January to December 2021.

Results 1206 alerts of the ASPSS were reviewed by the AMSP team and 434 of them (36%) generated prescription recommendations (one or more).

A total of 820 antibiotic recommendations were performed with a global acceptance of 78,3%.

A reduction of 10,6 DDD/100 s was found in 2021 compared to 2020 (58,42 DDD/100 s vs 69,02 DDD/100 s).

Conclusion and Relevance After the implantation of the AMSP, there was a decrease in the antibiotic use in 2021. Although other factors may have also contributed to this reduction, we confirm that a daily AMSP is a useful tool to optimise antimicrobial consumption.

It is necessary to continue with the implementation of the AMSP to guarantee the proper use of antimicrobials.

References and/or Acknowledgements None

Conflict of Interest No conflict of interest

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