Background and Importance Recent publications indicate that there are currently certain unmet needs shown by patients, highlighting the rapid onset of action and the persistence of the drug related to the increase in quality of life and the decrease in the stigma of the pathology. The appearance of new therapeutic targets presents us with a hopeful future in the treatment of psoriasis. In this context, it is of interest to know the persistence of gulselkumab, the first anti-IL 23 marketed in 2017.

Aim and Objectives To evaluate the persistence and complete skin clearance of guselkumab in all patients with moderate-severe psoriasis in our hospital.

Material and Methods Retrospective descriptive study conducted from the first prescription of guselkumab, May 2019, to September 2022. The electronic clinical record and the Farmatools application were used to record the following variables: age, sex, previous biological treatments, duration of therapy, posology and Psoriasis Area and Severity Index (PASI). The guselkumab regimen was 100 mg subcutaneously at weeks 0 and 4, followed by a maintenance dose of 100 mg every 8 weeks, in some patients the dose interval is longer in maintenance adjusted for drug response.

Results Forty-four patients were included (52% men), aged 54 ± 13 years. 50% of the patients were treated with a previous line, 39% with 2 or more lines, and 11% were naive for monoclonal antibody (mAbs). Two patients discontinued during induction due to primary failure and one due to adverse reaction. There were 2 losses to follow-up. The overall mean persistence was 758 ( ± 312 days).

Currently 32 patients continue in treatment with guselkumab, 61% presented PASI 0 in the last clinical evaluation. 34% have an optimised schedule: 22% every 10–12 weeks, 9% every 16 weeks, and one patient takes it every 24 weeks.

Conclusion and Relevance High levels of persistence and level of clearance of guselkumab in our clinical practice, which 90% of patients have been previously treated with mAbs, are in line with the 5 year results presented by Reich K. et al.

References and/or Acknowledgements 1. Zozaya, Néboa, et al. Unmet Needs in the Management of Moderate-to-Severe Psoriasis in Spain: A Multidimensional Evaluation. Acta Dermato-Venereologica (2022).

Conflict of Interest No conflict of interest