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Analysis of the clinical characteristics of dabigatran-induced oesophagitis
  1. Yulu Zhou1,
  2. Yanhong Su2,
  3. Zuojun Li1,
  4. Cuifang Wu1,
  5. Wei Sun1,
  6. Chunjiang Wang1
  1. 1 Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China
  2. 2 Department of Pharmacy, Yinan County Hutou Town Health Center, linyi, China
  1. Correspondence to Dr Chunjiang Wang, Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China; wongcj{at}


Objectives Dabigatran-induced oesophagitis has emerged in recent years. However, the incidence and clinical characteristics of patients with dabigatran-induced oesophagitis have not yet been clarified. The aim of this study was to examine the clinical characteristics of the disease.

Methods A retrospective analysis was undertaken of the literature on dabigatran-induced oesophagitis in Chinese and English from 2008 onwards.

Results There were 20 men (74.07%) and seven women (25.93%) in the study; their median age was 75 years (range 37–90). The main clinical symptoms were dysphagia (42.31%), odynophagia (26.92%), retrosternal pain (23.08%) and heartburn (23.08%). Endoscopy mainly showed sloughing mucosal casts (14 cases, 56%), ulcers (8 cases, 32%) and erosion (6 cases, 24%). The main injury sites were the mid to lower oesophagus (32%) and the mid oesophagus (32%). Withdrawal of dabigatran or giving the correct medication regimen resulted in rapid recovery of clinical symptoms from 1 day in some patients and up to 4 weeks, and mucosal recovery (2–5 weeks) in a median time of 3 weeks (range 0.29–48) in all patients.

Conclusions Oesophagitis is a rare complication of dabigatran with a good prognosis. Patients should be given proper medication instructions to prevent the occurrence of dabigatran-induced oesophagitis.

  • ethics
  • pharmacy
  • pharmacy administration
  • pharmacy service
  • hospital
  • clinical medicine
  • drug-related side effects and adverse reactions

Data availability statement

No data are available.

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