Article Text

Download PDFPDF

5PSQ-126 The analysis of interactions and potentially inappropriate medications in hospitalised seniors
  1. A Vicena1,
  2. S Kosirova2,
  3. H Komjathy1
  1. 1General Hospital Komarno, Hospital Pharmacy, Komarno, Slovakia
  2. 2Faculty of Pharmacy Commenius University, Department of Pharmacology and Toxicology, Bratislava, Slovakia


Background and Importance In our country should be placed greater emphasis to the health care of the elderly patients. It is necessary to monitor the drug-use, suggested to use the PIM wisely or prevent their use, monitor the possible interactions between drugs.

Aim and Objectives To follow the pharmacotherapy of the patients over the age 65 years hospitalised in the inpatient department of geriatric department for a half year (September-December 2018). Further, to analyse interactions between drugs, to monitor and quantify the PIMs, follow the number of hospitalisations and find correlations between these values.

Material and Methods Retrospective analysis of the medical records of 127 patients in age over 65 years hospitalised in the inpatient department of geriatric department, who were admitted at least on the day. Possible drug interactions were evaluated by program Lexicomp®. PIMs were evaluated according to the EU(7)-PIM list. Results were statistically analysed.

Results In the study group the average age was 83 [69–95;80] years. Each patient used 6 [0–15; 5] drugs/day. We identified 425 possible interactions, 3[0–13;0] interactions/patient. Only 26 patients did not have any drug interactions. The greatest value of used drugs in one patient was 16. Number of PIM/patient/day was 1[0–5;1]. The three most frequently used PIM were pantoprazole, alprazolam, digoxin. The difference in the number of PIM was statistically significant (p<0.05) in patients with/without interaction in therapy. There was confirmed a moderate relationship between the number of used drugs and the number of PIM (ρ=0.611, R2=0.915, p<0.01). In the study group patients were hospitalised 2[1–13;1] times in the period. There was found that the number of hospitalisations did not correlate with the number of used drugs (ρ=0.054, R2=0.0178, NS), or the number of PIMs (ρ=-0.002,R2=0.1249,NS), but had a weak relationship with the number of potential interactions (ρ=0.19,R2=0.5086;p<0.05).

Conclusion and Relevance In the observed group of hospitalised elderly patients one person took on average 6 drugs/day. There was found that if in the patient’s treatment more potential interactions are present, there is a greater likelihood of hospitalisation (p<0.05). Further, if a patient takes more drugs, there is a greater possibility to take a PIM (p<0.01).

References and/or Acknowledgements 1. Rodríguez-Perez A, et al. Validation of the LESS-CHRON criteria: reliability study of a tool for deprescribing in patients with multimorbidity. EJH Pharm. DOI: 10.1136/ejhpharm-2017-001476

Conflict of Interest No conflict of interest.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.