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NP-007 Validation of antimicrobial defined daily dose for the paediatric population: Final results of KiDDDs project
  1. E Montecatine-Alonso1,
  2. M Mejias-Trueba1,
  3. MV Gil-Navarro1,
  4. E Chavarri-Gil2,
  5. CM Fernandez-Llamazares3,
  6. E Dolz-Bubi4,
  7. JM Gutierrez-Urbon5,
  8. C Alvarez-Vayo1,
  9. P Suarez-Casillas1,
  10. S Lora-Escobar1
  1. 1Department of Pharmacy, Hospital Universitario Virgen del Rocio, Seville, Spain
  2. 2Department of Pharmacy, Hospital Universitario de Cruces, Barakaldo, Spain
  3. 3Department of Pharmacy, Hospital Gregorio Marañón, Madrid, Spain
  4. 4Department of Pharmacy, Complejo Hospitalario Universitario Insular-Materno Infantil, Las Palmas de Gran Canarias, Spain
  5. 5Department of Pharmacy, Complexo Hospitalario Universitario A Coruña, A Coruña, Spain


Background Antimicrobial stewardship programmes (ASPs) optimise antimicrobial use, improve patient outcomes, and reduce resistance. To assess the effectiveness of ASPs, it is necessary to have indicators that can be widely used. Defined daily dose (DDD) was designed by the World Health Organization for the adult population as a consumption indicator.

Objectives Validate the tool designed in phase I of the KiDDDs project to establish the most appropriate DDD values in the paediatric population.

Material and Methods This is an observational, retrospective, multicentre study consisting of two phases. The first phase was aimed at the theoretical calculation of paediatric DDD. The second phase constitutes the validation of the study.

Antimicrobial prescriptions were collected from the wards of seven Spanish hospitals during 2017 and 2018. Studied variables were age, gender, weight, antimicrobial dose, frequency and route of administration. Those antimicrobials included in the first stage were considered.

From the data collected, the total dose of antibiotic received per patient (mg/day) was calculated, subsequently, the median of the resulting DDD per antibiotic (g/day) was obtained (DDD-Phase II) and were compared with the theoretical DDD (DDD-Phase I).

Abstract NP-007 Table 1

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