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4CPS-095 Exploratory analysis of cardiovascular events in an asthmatic cohort
  1. VL Collada Sánchez1,
  2. E Villamañán1,
  3. P Granda2,
  4. C Mateos1,
  5. C Sobrino1,
  6. M Golovkina1,
  7. L De Las Vecillas3,
  8. D Laorden4,
  9. R Álvarez-Sala4,
  10. A Herrero1
  1. 1Hospital Universitario La Paz, Pharmacy, Madrid, Spain
  2. 2Hospital Gomez Ulla, Pharmacy, Madrid, Spain
  3. 3Hospital Universitario La Paz, Allergology, Madrid, Spain
  4. 4Hospital Universitario La Paz, Pneumology, Madrid, Spain


Background and Importance Asthma often accompanies a range of concurrent health conditions. However, there is a scarcity of evidence concerning the cardiovascular consequences in individuals with asthma.

Aim and Objectives The primary objective of the study was to analyse the impact of cardiovascular factors on a group of asthma patients in our hospital.

Material and Methods This was a retrospective, observational study including 206 patients with asthma who were assessed at the Difficult Asthma Control Unit of a tertiary hospital. Patients who had experienced a cardiovascular effect before the diagnosis of asthma were excluded.

We gathered demographic and clinical data, as well as comorbidities, asthma subtypes, biological markers and spirometric measurements using the electronic medical record via the HCIS application. We also documented the patients‘ cardiovascular event history, specifying the type of event. Furthermore, we recorded information regarding the patients‘ use of biological therapy, systemic corticosteroids and inhalation therapy

Results The majority of patients were women(65,6%) with an average age of 57±18 years. Among them, 121 patients had allergic asthma. Other comorbidities include: obesity or overweight(98), diabetes(24), hypertension(65), dyslipidemia(52) and sleep apnea (21).

108 patients were treated with omalizumab, 35 with mepolizumab, 18 with benralizumab and 40 werent receiving biological treatment. A total of 125 patients had more than 300 eosinophils and 110 had a total immunoglobulin E (IgE) level greater than 100 kU/L.

114 patients experienced at least one asthma exacerbation per year, while 109 patients had forced expiratory volume (FEV1) values <80% of predicted. 77 patients had a recent fraction of exhaled nitric oxide greater than 40 ppb.

23 patients (11%) suffered a cardiovascular event, including 5 anginas pectoris, 5 myocardial infarction, 6 heart failures, 8 supraventricular arrhythmias, 5 thromboembolisms, 5 strokes, and 1 with lower limb thrombosis.

Conclusion and Relevance Cardiovascular events are more prevalent in our asthmatic patients (11%) compared to the general European population (7%). It is essential to determine whether there is a relationship between cardiovascular processes and asthma, and if so, evaluate the mutual impact of both processes.

Conflict of Interest No conflict of interest.

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