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Evaluation of the use, effectiveness and safety of tyrosine kinase inhibitors in chronic myelogenous leukaemia in a general university hospital
  1. Iratxe Marquinez-Alonso1,2,
  2. Vicente Escudero-Vilaplana1,2,
  3. Santiago Osorio2,3,
  4. Carmen G Rodriguez-Gonzalez1,2,
  5. Eva González-Haba1,2,
  6. María Sanjurjo-Sáez1,2
  1. 1 Pharmacy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain
  2. 2 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain
  3. 3 Hematology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain
  1. Correspondence to Vicente Escudero-Vilaplana, Pharmacy Department. Hospital General Universitario Gregorio Marañón, Madrid 28007, Spain; vescudero.hgugm{at}salud.madrid.org

Abstract

Objectives To evaluate the use, effectiveness and safety of tyrosine kinase inhibitors (TKIs) for chronic myelogenous leukaemia (CML) in clinical practice.

Methods A retrospective longitudinal study of patients with CML who received TKIs for at least 6 months was performed. Endpoints to evaluate effectiveness were haematological, cytogenetic and molecular responses. Safety was assessed according to the occurrence of adverse events.

Results Sixty-two patients were included. All received imatinib as the initial TKI; 8% switched to nilotinib due to lack of major molecular response (MMR) to imatinib and 3% switched to dasatinib because of progression to blast crisis or lack of MMR. At the end of the study all patients had achieved at least a complete cytogenetic response. With regard to safety, in 11 patients the dose of imatinib was decreased and four patients switched to a second-generation TKI due to imatinib toxicity.

Conclusions Considering the good responses of most patients and its better known safety profile, imatinib should remain a good option for first-line treatment of CML.

  • chronic myelogenous leukemia
  • dasatinib
  • effectiveness
  • imatinib
  • nilotinib
  • real world data
  • safety
  • tyrosine-kinase inhibitors

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