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Prevalence of pulmonary arterial hypertension in the Camerino area of central Italy and savings resulting from generic bosentan
  1. Sonia Natali1,
  2. Martina Palmieri1,
  3. Carlo Polidori2
  1. 1Hospital Pharmacy of the Santa Maria Hospital of Camerino, Camerino, Italy
  2. 2Experimental Medicine and Public Health Department, University of Camerino, Camerino, Italy
  1. Correspondence to Dr. Sonia Natali, Hospital Pharmacy of the Santa Maria Hospital of Camerino, Camerino 62032, Italy; sonia.natali{at}sanita.marche.it

Abstract

Objective Pulmonary arterial hypertension is a rare and progressive respiratory disease characterised by high blood pressure and vascular resistance producing right ventricular fatigue. In Italy, pulmonary hypertension can be treated with different drugs available on the market at different costs, and in the Marche region distributed exclusively by hospital pharmacies. The present study examined in an area of the Marche region the use of drugs specifically indicated for pulmonary hypertension, and evaluated how the introduction of the generic bosentan might lower pharmaceutical costs for the healthcare budget.

Methods The study examined oral administration prescriptions and costs using data from the Apotheke Gold (Record Data) database from 1 January 2012 to 31 August 2017.

Results Annually (from 1 January 2012 to 31 August 2017), an average of 4.83 patients were treated (prevalence of 102.35 cases per 1 million residents) with ambrisentan (Volibris), bosentan (Tracleer), macitentan (Opsumit), tadalafil (Adcirca) or sildenafil (Revatio). The total expenditure during the 5-year 8-month period was €472 405. Ambrisentan was by far the most expensive product overall, with a total expenditure of €222 380 for the period studied (a daily cost of €67.39), even though Tracleer had the highest cost for a day of treatment (a daily cost of €94.48, but a total expenditure of €163 976 for the period, due to its more recent marketing). Providing patients with the generic form bosentan in place of Tracleer would lower the costs dramatically. A very significant annual savings per patient of approximately €31 879 would be achieved, a striking 92.4% reduction in costs.

Conclusion The prevalence of pulmonary arterial hypertension reported for Camerino and its surrounding area in the Marches region is quite high compared with that reported by other authors for France and Scotland. The introduction of the generic bosentan would cut costs drastically. It is to be hoped that centralised procurement at the regional level would bring further savings.

  • pharmacoeconomics
  • pharmacy management (organisation, financial)
  • drug procurement
  • ethics (see medical ethics)
  • health economics

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