Article Text

PDF
Current situation of carboplatin desensitisation protocols in the hospitals of Spain
  1. Rocío Vázquez Sánchez1,
  2. Javier Sánchez-Rubio Ferrández1,
  3. Damián Córdoba-Díaz2,
  4. Manuel Córdoba-Díaz2,
  5. Raúl Díez-Fernández1,
  6. Teresa Molina-Garcia1
  1. 1 Pharmacy, Hospital Universitario de Getafe, Getafe, Spain
  2. 2 Pharmacy, Universidad Complutense, Madrid, Spain
  1. Correspondence to Rocío Vázquez Sánchez, Pharmacy, Hospital Universitario de Getafe, Getafe 28905, Spain; rovazsan{at}hotmail.com

Abstract

Desensitisation protocols allow the continuation of treatment in patients who have presented hypersensitivity reactions. Carboplatin desensitisation solutions are usually prepared in the chemotherapy centralised units of hospital pharmacies and they are diluted under the established concentration limit to guarantee the stability of the preparation. An online survey was sent to hospital pharmacies, inquiring about local desensitisation protocols: reasons for use of desensitisation protocols, the protocols used and the stability given to carboplatin solutions. An important variability among the hospitals in carboplatin desensitisation practice was detected. Six different carboplatin desensitisation protocols were described and discordance with the storage period of the carboplatin solutions was observed. The lack of consensus on which protocol must be followed and data supporting the stability of the diluted product, contribute to distrust of carboplatin desensitisation protocols. Although the efficacy and safety of carboplatin desensitisation protocols has been widely demonstrated, many professionals still have concerns.

  • carboplatin
  • drug stability
  • desensitisation
  • hypersensibility
  • survey

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.