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Review of economic data on closed system transfer drug for preparation and administration of hazardous drugs
  1. Annaelle Soubieux1,
  2. Cynthia Tanguay1,
  3. Jean Lachaine2,
  4. Jean-François Bussières1,2
  1. 1 Pharmacy practice research unit, CHU Sainte-Justine, Montreal, Canada
  2. 2 Faculté de pharmacie, Université de Montréal, Montreal, Canada
  1. Correspondence to Jean-François Bussières, Unité de Recherche en Pratique Pharmaceutique, Département de pharmacie, Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC H3T 1C5, Canada; jf.bussieres{at}


Objectives The objectives of this study were to review economic data on the use of closed system drug transfer devices (CSTDs) for preparing and administering hazardous drugs, and to evaluate the quality of data reporting as defined by the Consolidated Health Economic Evaluation Reporting Standards (CHEERS).

Methods All references from a recent Cochrane review about CSTDs were evaluated for inclusion. A literature review was also conducted. Articles containing economic data about the use of CSTDs were retained for analysis. Two researchers independently graded the articles according to the 24-item CHEERS checklist.

Results Of the 138 articles identified initially, 12 were retained for analysis. Nine of these studies did not report acquisition costs or did not detail acquisition costs. Six studies reported economic benefits associated with the used of CSTDs, all related to extending the beyond-use date. The mean number of CHEERS criteria fulfilled by the included articles was 9.2 (SD 2.4).

Conclusions CSTDs are costly to acquire. However, few studies have examined the economic impact of these devices, and the existing studies are incomplete. As a result, hospitals planning to implement these devices will be unable to make a sound economic evaluation. Robust economic evaluation of CSTDs is needed.

  • closed system drug transfer device
  • hazardous drug
  • economic evaluation
  • compounding
  • preparation
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