Article Text

Download PDFPDF
Application of vancomycin in patients with augmented renal clearance
  1. Yang Chu1,2,
  2. Yifan Luo2,
  3. Mingyan Jiang2,
  4. Baosen Zhou1
  1. 1 Department of Clinical Epidemiology and Center of Evidence-Based Medicine, The First Affiliated Hospital, China Medical University, Shenyang, China
  2. 2 Department of Pharmacy, The First Affiliated Hospital, China Medical University, Shenyang, China
  1. Correspondence to Professor Baosen Zhou, Department of Clinical Epidemiology and Center of Evidence-Based Medicine, The First Affiliated Hospital, China Medical University, Shenyang, 110001, China; bszhou{at}cmu.edu.cn

Abstract

Objective To analyse the influence of factors on the steady-state trough concentration (Ctrough) of vancomycin, especially in patients with augmented renal clearance, and to provide a reference for clinical application.

Methods Data on patient demographics, routine blood examination, hepatic function and kidney function were collected from May 2013 to October 2016. A total of 292 patients were enrolled and correlations between Ctroughof vancomycin and other test indices were analysed by SPSS software.

Results The patients with augmented renal clearance were significantly younger with relatively lower Ctrough values and higher weight, ALB and PLT compared to others. And age was the most important factor of Ctroughamong subgroups of ARC.

Conclusions Inpatients with augmented renal clearance,vancomycin Ctrough was mainly affected by age. Clinicians and pharmacists should adjust the dosage regimen in a timely manner based on therapeutic drug monitoring and these influencing factors.

  • vancomycin
  • serum trough concentration
  • creatinine clearance
  • augmented renal clearance
  • therapeutic drug monitoring
View Full Text

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.