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Advanced cutaneous squamous cell carcinoma (cSCC) with nodal and/or distal metastases or large local spreading is inoperable, and treatment options for patients are usually limited to chemotherapy and radiation. The National Comprehensive Cancer Network (NCCN) Guidelines include some regimens of cisplatin- (CDDP) based systemic therapies, but no chemotherapy has yet been established for advanced cSCC.1 Peplomycin sulfate, bleomycin, and irinotecan are licensed for cSCC in Japan but are not commonly used in actual clinical practice because of their low efficacy and severe side effects (such as interstitial pneumonia, myelosuppression, and adverse digestive symptoms). CA regimen, the combination of CDDP and adriamycin (ADM), has been reported to show a response rate of about 60% for advanced cSCC,2 whereas other …
Contributors MO, TK, MK and MH designed the study. MO, TK, EM, TN, RO, MS and MM contributed to the data collection. MO, TK, ST, AT, MK, HM and MH contributed to analysis and interpretation of data, and assisted in the preparation of the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; internally peer-reviewed.
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