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Combination of ceftaroline and daptomycin as treatment for complicated osteomyelitis
  1. Ana Gascón1,
  2. Marta Castresana1,
  3. Natalia Alzueta2,
  4. Marta Marin1,
  5. María Pío1,
  6. Aitziber Echeverria3
  1. 1Pharmacy, Hospital Reina Sofia Navarre Health Service, Tudela, Spain
  2. 2Pharmacy Management Service, Navarre Health Service, Pamplona, Spain
  3. 3Internal Medicine, Hospital Reina Sofia, Navarre Health Service, Tudela, Spain
  1. Correspondence to Ana Gascón, Pharmacy, Hospital Reina Sofia, Tudela, Navarra, Spain; am.gascon.villacampa{at}navarra.es

Abstract

Osteomyelitis is an infection involving bone. Staphylococcus aureus is the pathogen most frequently implicated; less frequently involved are other gram-positive organisms, such as Staphylococcus epidermidis, and also gram-negative organisms. The antibiotic of choice for treatment of osteomyelitis caused by methicillin-resistant staphylococci (MRS) is vancomycin, although other alternatives such as daptomycin or teicoplanin are also considered. Osteomyelitis caused by MRS can be difficult to treat safely and effectively. This case report describes the successful use of daptomycin combined with ceftaroline for the treatment of osteomyelitis caused by methicillin-resistant S. epidermidis (MRSE) in a 54-year-old woman, emphasising the clinical pharmacist’s role in antimicrobial stewardship programmes. This alternative combination has been studied in the treatment of methicillin-resistant S. aureus (MRSA), but it may also be useful in MRSE.

  • microbiology
  • infection control
  • hospital pharmacy education
  • microbiological control
  • pharmacokinetics and dynamics
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