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Levofloxacin induced bullous fixed drug eruption: a rare case report
  1. Amit Sharma1,2,
  2. Ashish Baldi3,
  3. Dinesh Kumar Sharma4
  1. 1Department of Pharmacy Practice, ISF College of Pharmacy, Moga, Punjab, India
  2. 2Department of Pharmacy, Uttarakhand Technical University, Dehradun, Uttarakhand, India
  3. 3Department of Pharmaceutical Science and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India
  4. 4Department of Pharmaceutics, Himalayan Institute of Pharmacy & Research, Dehradun, Uttarakhand, India
  1. Correspondence to Dr Amit Sharma, Department of Pharmacy Practice, ISF College of Pharmacy, Moga 142001, Punjab, India; choice.amit{at}gmail.com; Dr Ashish Baldi, Department of Pharmaceutical Science and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India; ashishbaldi{at}gmail.com

Abstract

A 42-year-old male patient visited the outpatient department for follow-up with a history of respiratory tract infection and diabetes mellitus. His main symptom was peeling of his epidermal layer of skin, and bullous fixed drug eruption on the lower and upper limbs and bank region of the body. Following assessment, the patient was prescribed levothyroxine, hydroxychloroquine, levofloxacin, and a combination of sulfamethoxazole-trimethoprim. On assessing causality of the adverse drug reaction (ADR), different ADR assessment scales such as the WHO-UMC Scale, Naranjo Scale, and Hartwig’s Severity Assessment Scale were used, and the ADR was found by these scales to be ‘likely’, ‘moderate’, and ‘probable’, respectively. It was found that ADRs such as bullous fixed drug eruptions are not fatal but can cause patient anxiety and a reduced quality of life. This case report will help physicians and clinicians to become aware and vigilant about the ADR caused by levofloxacin, facilitating its early detection and management.

  • drug-related side effects and adverse reactions
  • diabetes mellitus
  • education
  • pharmacy
  • continuing
  • drug misuse
  • education department
  • hospital
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