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The potential for deprescribing in a palliative oncology patient population: a cross-sectional study
  1. Lisanne N van Merendonk1,
  2. Bas J M Peters1,
  3. Julia E Möhlmann1,
  4. Cornelis B Hunting2,
  5. Elisabeth A Kastelijn3,
  6. Marcel P H van den Broek1
  1. 1Clinical Pharmacy, Sint Antonius Hospital, Nieuwegein, The Netherlands
  2. 2Department of Internal Medicine, Sint Antonius Hospital, Nieuwegein, The Netherlands
  3. 3Department of Pulmonary Diseases, Sint Antonius Hospital, Nieuwegein, The Netherlands
  1. Correspondence to Lisanne N van Merendonk, Clinical Pharmacy, Sint Antonius Hospital, Nieuwegein 1066CX, The Netherlands; l.v.merendonk{at}nki.nl

Abstract

Objectives The use of preventive medication in palliative oncology patients may be inappropriate due to limited life expectancy. Deprescribing tools are available but time-consuming and not always tailored to this specific population. Our primary goal was to identify potentially inappropriate medications (PIMs) in palliative oncology patients with a life expectancy of up to 2 years using an adapted deprescribing tool. Our secondary aim was to identify patient characteristics associated with the presence of PIMs.

Methods Oncology patients with a life expectancy of up to 2 years were included cross-sectionally. An adapted deprescribing tool was developed to identify PIMs. Logistic regression was used to identify factors associated with having PIMs.

Results A total of 218 patients were included in this study of which 56% had at least one PIM with a population mean of 1.1 PIM per patient. Most frequently defined PIMs were antihypertensive drugs and gastric acid inhibitors. Identification of PIMs by review took an estimated 5–10 min per patient. Polypharmacy, age >65 years and inpatient/outpatient status were found to be associated with having at least one PIM.

Conclusions Deprescribing is possible in more than half of palliative oncology patients with a life expectancy of up to 2 years. The adapted deprescribing tool used is non-time consuming and suitable for palliative oncology patients, regardless of age.

  • palliative care
  • medical oncology
  • pharmacy service, hospital
  • preventive medicine
  • drug misuse

Data availability statement

Data are available upon reasonable request.

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Data availability statement

Data are available upon reasonable request.

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