Article Text

Download PDFPDF
Real-world effectiveness and durability of dual antiretroviral therapy in HIV-infected patients
  1. Laia Pérez-Cordón1,
  2. Azhara Sánchez1,
  3. Sergio Marin2,
  4. Lluis Force3,
  5. Mateu Serra-Prat4,
  6. Elisabet Palomera4,
  7. Lluis Campins1
  1. 1Pharmacy Department, Hospital de Mataró, Mataró, Spain
  2. 2Pharmacy Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
  3. 3Department of Internal Medicine, Hospital de Mataró, Mataró, Spain
  4. 4Research Unit, Hospital de Mataró, Mataró, Spain
  1. Correspondence to Laia Pérez-Cordón, Pharmacy Department, Hospital de Mataró, Mataro 08304, Spain; lperez{at}csdm.cat

Abstract

Background and objectives While randomised controlled trials in HIV-infected patients have shown that certain dual antiretroviral therapy (DAT) regimens are non-inferior in terms of efficacy compared with classical triple-drug regimens, few real clinical experiences have been described. The aim of the study was to investigate, in real clinical practice, DAT effectiveness, durability, and risk factors for treatment discontinuation.

Methods This was a prospective cohort study that included HIV-infected patients treated with DAT (2015–2020). DAT was considered effective when patients achieved or maintained virological suppression and was assessed at 24 and 48 weeks. DAT durability was evaluated using the Kaplan-Meier method. Adherence and treatment cost were compared with patients’ previous antiretroviral regimens.

Results 51 patients were included, 27.5% with HIV-1 RNA ≥50 copies/mL at baseline, treated with a wide range of dual combinations. At 48 weeks follow-up, 83.8% and 50.0% of patients who started DAT with HIV-1 RNA <50 copies/mL and ≥50 copies/mL, respectively, were suppressed. 39 out of 51 patients (76.5%) maintained DAT for a mean treatment duration of 40.5±14.8 weeks. Full adherence was observed in 78.4% of patients compared with 70.2% in the previous regimen. Mean daily cost was €18.6±4.3 compared with €16.1±7.9 in the previous regimen (p=0.008).

Conclusion DAT effectiveness and durability were higher in patients who were virologically suppressed at baseline. DAT is a possible alternative for virologically non-suppressed patients who cannot be treated with a triple-drug regimen.

  • HIV
  • Drug Monitoring
  • PHARMACY SERVICE, HOSPITAL
  • Quality of Health Care
  • Practice Guideline

Data availability statement

No data are available.

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.