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A new function in the Stabilis database: physical compatibility and incompatibility of injectable drugs to secure Y-site administration
  1. Benoît Beiler1,2,
  2. Jean Vigneron1,2,
  3. Elise D'Huart1,2,
  4. Béatrice Demoré1,2,3
  1. 1Pharmacy, Centre Hospitalier Régional Universitaire de Nancy, Vandoeuvre-les-Nancy, France
  2. 2Infostab, Heillecourt, Grand Est, France
  3. 3UL UR APEMAC, Vandoeuvre-les-Nancy, Grand Est, France
  1. Correspondence to Mr Benoît Beiler, Pharmacy, Centre hospitalier régional universitaire de Nancy, Vandoeuvre-les-Nancy, France; benoitbeiler{at}


Objectives In intensive care units, the mixing of injectable drugs via Y-site administration is often necessary. However, some mixtures can lead to physical incompatibility or chemical instability. To assist healthcare professionals, several databases such as Stabilis compile compatibility and stability data. The objectives of this study were to update the online database Stabilis by adding physical compatibility data to the website and to characterise the incompatibility data already present in the database by specifying the phenomenon at the origin of the incompatibility and its time of occurrence.

Methods Bibliographic sources referenced in Stabilis were evaluated using several criteria. After the evaluation, studies were rejected or the data they contain were added to the database. Data entries contained the following information: name of the two injectable drugs involved in the mixture and their concentration if available, the dilution solvent and the phenomenon at the origin of the incompatibility and its time of occurrence for incompatibility data. Three functions of the website were modified, including the ‘Y-site compatibility table’ function, which allows creation of customised compatibility tables.

Results A total of 1184 bibliographic sources were evaluated, 77.3% (n=915) of which were scientific articles, 20.5% (n=243) were Summaries of Product Characteristics and 2.2% (n=26) were communications in a pharmaceutical congress. After evaluation, 28.9% (n=342) of the sources were rejected. From the 71.1% (n=842) sources selected, 8073 (70.2%) compatibility data entries and 3433 incompatibility data entries (29.8%) were made. With the addition of these data, the database contained compatibility and incompatibility data for 431 injectable drugs.

Conclusions Since the update, the ‘Y-site compatibility table’ function has seen its traffic increased by about 66% (∼1500 tables per month compared with ∼2500 tables per month). Stabilis is now more complete to offer significant help to healthcare professionals with their problems of drug stability and compatibility.

  • Drug Administration Routes
  • Critical Care

Data availability statement

No data are available.

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