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Polymyxin B-related neurotoxicity: a brief case report
  1. Izgi Bayraktar1,
  2. Burcin Halacli2,
  3. Kutay Demirkan1,
  4. Arzu Topeli2
  1. 1Department of Clinical Pharmacy, Hacettepe University Faculty of Pharmacy, Ankara, Turkey
  2. 2Department of Internal Medicine, Division of Intensive Care Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey
  1. Correspondence to Izgi Bayraktar, Department of Clinical Pharmacy, Hacettepe University Faculty of Pharmacy, Ankara, Turkey; izgibayraktar{at}


Polymyxin B and colistin are considered the last therapeutic option to treat infections caused by highly drug-resistant bacteria. However, their administration may lead to various adverse effects such as nephrotoxicity, neurotoxicity, and allergic reactions. The current case report presents the clinical manifestation of polymyxin B-associated neurotoxicity in a female patient with no chronic illness history. The patient was rescued from under rubble during an earthquake. She was diagnosed with an intra-abdominal infection caused by Acinetobacter baumannii (A. baumannii). After the initiation of the polymyxin B infusion, the patient developed numbness and tingling sensations in her hands, face, and head. On discontinuing polymyxin B and starting colistimethate, the patient’s symptoms improved. Therefore, healthcare professionals should be aware of the potential risk factors associated with neurotoxicity in patients receiving polymyxin B. On identifying such symptoms treatment should be discontinued promptly to prevent further neurological damage.

  • Case Reports
  • Critical Care

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