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Correlation between antibiotic use and resistance of gram-negative bacteria at a university hospital in Japan from 2013 to 2021: a study using the Japan Surveillance for Infection Prevention and Healthcare Epidemiology system
  1. Keisuke Kagami1,2,
  2. Nobuhisa Ishiguro2,
  3. Sumio Iwasaki2,3,
  4. Keisuke Taki2,3,
  5. Tatsuya Fukumoto2,3,
  6. Kasumi Hayasaka2,3,
  7. Reiko Oyamada2,
  8. Tsubasa Watanabe2,
  9. Sho Nakakubo2,4,
  10. Yusuke Niinuma1,2,
  11. Mitsuru Sugawara1,5,
  12. Yoh Takekuma1
  1. 1Department of Pharmacy, Hokkaido University Hospital, Sapporo, Japan
  2. 2Department of Infection Control and Prevention, Hokkaido University Hospital, Sapporo, Japan
  3. 3Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan
  4. 4Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan
  5. 5Laboratory of Pharmacokinetics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
  1. Correspondence to Dr Keisuke Kagami, Department of Pharmacy, Hokkaido University Hospital, Sapporo, Hokkaido 060-8648, Japan; kkagami{at}huhp.hokudai.ac.jp

Abstract

Objectives The Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system aggregates information related to antimicrobial resistance (AMR) measures. We aimed to investigate the correlation between antibiotic use and AMR at a university hospital from 2013 to 2021 in a time series analysis using the J-SIPHE system. We also studied this correlation in each ward (inter-ward analysis).

Methods Data on antibiotic use and resistance rates were collected from the J-SIPHE system, except for the resistance rate in each ward, which was calculated from the source data prepared for this system.

Results Piperacillin/tazobactam use was positively correlated with piperacillin/tazobactam resistance in Escherichia coli and Klebsiella pneumoniae in the inter-ward analysis, and in Pseudomonas aeruginosa in both analyses. Carbapenem use was positively correlated with meropenem resistance in Enterobacter cloacae in the time series analysis and in P. aeruginosa in both analyses, and imipenem/cilastatin resistance in P. aeruginosa in inter-ward analysis. Quinolone use was positively correlated with levofloxacin resistance in E. coli in both analyses, and in K. pneumoniae in inter-ward analysis.

Conclusions This is the first study to investigate the correlation between antibiotic use and AMR at a single hospital in time series and inter-ward analyses using the J-SIPHE system and data prepared for this system, suggesting that this system may be useful for promoting AMR measures.

  • J-SIPHE
  • surveillance
  • antibiotic use
  • antibiotic resistance
  • carbapenems

Data availability statement

No data are available.

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