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Factors influencing accuracy when preparing injectable drug concentrations in appliance with clinical practice: a norepinephrine case study
  1. Sixtine Gilliot1,2,
  2. Anthony Martin Mena2,
  3. Stéphanie Genay1,2,
  4. Morgane Masse1,2,
  5. Manon Thibaut2,
  6. Natacha Carta2,
  7. Damien Lannoy1,2,
  8. Laura Négrier2,
  9. Christine Barthélémy2,
  10. Bertrand Décaudin1,2,
  11. Pascal Odou1,2
  1. 1Institute of Pharmacy, CHRU Lille Pôle Spécialités Médicochirurgicales, Lille, Hauts-de-France, France
  2. 2ULR-7365 Groupe de Recherche sur les formes Injectables et les Technologies Associées, University of Lille, Lille, Hauts-de-France, France
  1. Correspondence to Sixtine Gilliot, ULR-7365 Groupe de Recherche sur les formes Injectables et les Technologies Associées, University of Lille, 59000 Lille, Hauts-de-France, France; sixtine.gilliot{at}


Errors in injectable preparations with high-risk drugs can be fatal. This study aimed to identify the factors influencing the accuracy of high-risk injectable drug concentrations in appliances used for intensive care unit preparation practices. Norepinephrine (NE) was chosen as an example of a high-risk medication drug. The concentration (0.2 and 0.5 mg/mL), the diluent (sodium chloride 0.9% and 5% dextrose), and the container type (prefilled- and empty-infusion bag and syringe) were tested as potential variability factors. An ultraviolet spectrophotometric method was used for NE dosage. 108 NE solutions were prepared by five individuals (pharmacists or laboratory technicians) with clinical experience as well as experience in the aseptic preparation of solutions. The container type was found to be the only factor influencing the accuracy of NE concentration. NE solutions in syringes proved to be the most accurate while preparations in prefilled bags tended to underdose NE.

  • Critical Care
  • Administration, Intravenous
  • Drug Compounding

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