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Assessment of particle contamination in vancomycin syringe pumps following fluid withdrawal using three diverse aseptic reconstitution techniques
  1. Roland Benjamin van den Berg1,2,
  2. Minke M van Bommel1,
  3. Lennart J Stoker1,
  4. Elsbeth M Westerman1
    1. 1Department of Hospital Pharmacy, Haaglanden Medisch Centrum, The Hague, The Netherlands
    2. 2Department of Clinical Pharmacology and Pharmacy, Amsterdam UMC, location Vrije Universiteit, Amsterdam, The Netherlands
    1. Correspondence to Roland Benjamin van den Berg, Department of Hospital Pharmacy, Haaglanden Medisch Centrum, The Hague, The Netherlands; roland.van.den.berg{at}

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    The recommended approach for administering vancomycin involves intermittent peripheral infusion at a concentration of 5 mg/mL,1 while continuous central venous infusion has gained ground due to the reduced risk of renal injury and heightened probability of attaining pharmacokinetic objectives compared with intermittent dosing.2 However, adhering to the recommended concentration of 5 mg/mL for continuous vancomycin administration notably increases the total volume and necessitates frequent syringe replacements compared with concentrations ≥20 mg/mL. Within our hospital setting, vancomycin is administered via continuous infusion at a concentration of 40 mg/mL to mitigate fluid overload and reduce the need for frequent syringe changes.

    Recently, Masse et al demonstrated that non-filtered vancomycin solutions at concentrations ranging from 25 to 80 mg/mL diluted in sodium chloride (NaCl) 0.9% and water for injections exceeded the European Pharmacopoeia …

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    • Contributors Data collection was performed by RB and MB. RB conducted the analyses and wrote the first draft of the paper. MB, LS and EW made critical revisions to the draft.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.