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Ceftriaxone-induced thrombocytopenia during tuberculosis treatment: a case report
  1. Matthijs Plas1,
  2. Linda M Kampschreur1,
  3. Johannes A Kroes2,
  4. Leendert Porcelijn3,
  5. Carina Bethlehem2,4
    1. 1Department of Internal Medicine, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
    2. 2Department of Clinical Pharmacy and Pharmacology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
    3. 3Department of Immunohepatology Diagnostics, Sanquin Diagnostic Services, Amsterdam, The Netherlands
    4. 4Department of Intensive Care, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
    1. Correspondence to Dr Matthijs Plas; matthijsplas{at}live.nl; Carina Bethlehem; Carina.Bethlehem{at}mcl.nl

    Abstract

    We present a case of drug-induced immune thrombocytopenia (DITP) proven to be due to ceftriaxone instead of assumed tuberculostatic treatment in a patient with miliary tuberculosis. It is important to identify the culprit drug in DITP to avoid discontinuing essential treatment, especially when more than one drug is implicated. In these cases additional analysis (drug-dependent platelet antibody testing) should be considered to prevent unnecessary replacement of a first-line regimen of tuberculostatic treatment with an alternative treatment regime.

    • Case Reports
    • Clinical Laboratory Techniques
    • DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS
    • Antimicrobial Stewardship
    • PULMONARY MEDICINE

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