TY - JOUR T1 - Chapter 5: Appraising the evidence JF - European Journal of Hospital Pharmacy: Science and Practice JO - Eur J Hosp Pharm SP - 134 LP - 138 DO - 10.1136/ejhpharm-2014-000469 VL - 21 IS - 3 AU - Phil Wiffen AU - Tommy Eriksson AU - Hao Lu Y1 - 2014/06/01 UR - http://ejhp.bmj.com/content/21/3/134.abstract N2 - Evidence-based Pharmacy was first published as a book by Phil Wiffen in 2001. The first chapter was published in Eur J Hosp Pharm 2013;20:308–12.In the first edition of Evidence-based Pharmacy, Chapter 5 covered issues on accessing evidence. Since that time, accessing information via search engines on the internet has become commonplace such that it no longer warrants a separate chapter.This chapter now deals with tools that can be used for assessing the quality of evidence using appraisal tools. While we may think that quality is assured by processes such as peer review or even the reputation of a particular journal, in reality that is often not the case. It is important that we make our own judgement before using an article in our practice. In this chapter, tools to help with that appraisal process for a range of study designs are presented. At the end of this article, we present some thoughts on appraising patient-oriented outcomes.We present an algorithm to help identify study designs (figure 1). This is based on an idea from SIGN.1Figure 1 Algorithm of study designs. There are two ways to test a hypothesis, either by observation or by experiment. Observational research In observational research, the researcher observes a population or group of patients or manipulates data about these patients. Such data may come from interviews or from existing data sets such as prescription analysis data or registries for particular diseases such as cancer or infectious disease. Surveys and case control studies are examples of observational research. A great deal of the research around pharmacy services is, of necessity, observational in style. Observational research is likely to be more biased but is still necessary and sometimes the only means to answer certain questions. Experimental research In experimental research, an intervention is performed as part of a planned … ER -