RT Journal Article
SR Electronic
T1 Visual compatibility of insulin aspart with intravenous drugs frequently used in ICU
JF European Journal of Hospital Pharmacy
JO Eur J Hosp Pharm
FD British Medical Journal Publishing Group
SP 123
OP 124
DO 10.1136/ejhpharm-2014-000478
VO 22
IS 2
A1 Voirol, Pierre
A1 Berger-Gryllaki, Markoulina
A1 Pannatier, André
A1 Eggimann, Philippe
A1 Sadeghipour, Farshid
YR 2015
UL http://ejhp.bmj.com/content/22/2/123.abstract
AB Objective Insulin as continuous infusion is frequently used in critical care. Data on compatibilities are available for regular insulin but not for insulin aspart. The present study aimed at assessing the physical compatibility of insulin aspart with 47 drugs commonly used in intensive care units by simulated Y-site administration. Methods The physical compatibility of insulin aspart 1 IU/mL in sodium chloride 0.9% and in dextrose 5% was evaluated by visual inspection over a 24 h period. Tested drugs were diluted in the same solvents or tested without dilution, based on standard practices. Tests were conducted in duplicates. Results Insulin aspart was compatible over 24 h with 43 drugs over the 47 selected. Imipenem-cilastin, meropenem, esomeprazole and pantoprazole were compatible over a shorter period. Conclusions Of the 47 drugs tested, only four were not physically compatible over 24 h. Our data will allow a switch from regular insulin to insulin aspart if needed.