TY - JOUR T1 - DI-032 Antiretroviral therapy, adherence and quality of life in older hiv-patients with moderate-high cardiovascular risk JF - European Journal of Hospital Pharmacy JO - Eur J Hosp Pharm SP - A87 LP - A87 DO - 10.1136/ejhpharm-2015-000639.209 VL - 22 IS - Suppl 1 AU - E Domingues AU - M Ferrit AU - M Calleja Y1 - 2015/03/01 UR - http://ejhp.bmj.com/content/22/Suppl_1/A87.3.abstract N2 - Background The availability of more potent drugs, with fewer adverse effects, and new therapeutic strategies, such as simplification and ritonavir-boosted protease inhibitor (PI/r) monotherapy have changed the antiretroviral therapeutic profile of HIV patients.Purpose To analyse the relationship between antiretroviral therapy (ART), adherence and health-related quality of life (HRQL) in HIV patients older than 50 years, with moderate-high cardiovascular risk (CVR), integrated in a pharmacotherapy follow-up service.Material and methods Patients on antiretroviral therapy aged over 50, with a CVR ≥ 2 (assessed by the risk score), who signed an informed consent were included. Study variables were obtained through interview, clinical history and pharmacy records. The HRQL was assessed through the MOS-HIV questionnaire1 and the adherence by the SMAQ questionnaire and electronic dispensing record.Results We included 73 patients, 84% males, median age 54 years (IQR 52–59) who had been diagnosed with HIV for 17 years (IQR 13–20). Median CD4 count 684 cells/mm3 (IQR 469–882) and 93% with undetectable viral load. Adherence according to dispensing records was 93% (89–98) and by SMAQ, 67% were adherent. The most prescribed antiretrovirals were darunavir and tenofovir, 32% of patients had been prescribed an unconventional regimen and 29% PI/r monotherapy, median of three tablets/day (IQR 3–4) and 75% once daily. The domains of HRQL, physical (PHS) and mental (MHS) were significantly higher in: patients over 60 years, patients with more than 10 years of ART and with fewer than 3 tablets/day. Patients not on IP/r had higher scores on all dimensions of HRQL with significant differences in cognitive functioning (p = 0.015).Conclusion Patients presented antiretroviral therapy in unconventional combinations, more than 90% adherence and undetectable viral load. Antiretroviral treatment strategy could improve the quality of life perceived by the patient.ReferenceWu AW, Rubin HR, Mathews WC, et al. A health status questionnaire using 30 items from the Medical Outcomes Study: Preliminary validation in persons with early HIV infection. Medical Care 1991;29(8):786–98ReferenceNo conflict of interest. ER -