RT Journal Article SR Electronic T1 Evaluation of chemical contamination of surfaces during the preparation of chemotherapies in 24 hospital pharmacies JF European Journal of Hospital Pharmacy JO Eur J Hosp Pharm FD British Medical Journal Publishing Group SP 333 OP 341 DO 10.1136/ejhpharm-2014-000549 VO 22 IS 6 A1 Fleury-Souverain, Sandrine A1 Mattiuzzo, Marc A1 Mehl, Florence A1 Nussbaumer, Susanne A1 Bouchoud, Lucie A1 Falaschi, Ludivine A1 Gex-Fabry, Marianne A1 Rudaz, Serge A1 Sadeghipour, Farshid A1 Bonnabry, Pascal YR 2015 UL http://ejhp.bmj.com/content/22/6/333.abstract AB Purpose To evaluate the chemical contamination of surfaces by cytotoxic agents during preparation of injectable chemotherapies in hospital pharmacies.Methods 526 wipe samples collected in 24 Swiss hospital pharmacies were analysed using a validated liquid chromatography–mass spectrometry/mass spectrometry method able to quantify 10 cytotoxic agents: cytarabine, gemcitabine, cyclophosphamide, ifosfamide, methotrexate, etoposide phosphate, irinotecan, doxorubicin, epirubicin and vincristine. Information on chemotherapies produced, equipment and production processes used were collected from all the hospital pharmacies on a voluntary basis in order to investigate their association with contamination rates.Results In two pharmacies, no trace of the 10 cytotoxic agents was detected. Chemical contamination was found in the other 22 hospital pharmacies, with combined total contamination of the 10 cytotoxic agents ranging from 8 ng to more than 41 000 ng per sample. Most contaminated samples came from inside biosafety cabinets, but some came from other clean room areas and logistics rooms. Statistically significant associations were observed between contamination rates and sampling locations, the number of chemotherapies prepared per year and types of cleaning solutions used.Conclusions This study demonstrated that most of the hospital pharmacies tested had some contamination of surfaces by different cytotoxic agents. Even if highest levels of contamination were mainly detected inside biosafety cabinets, technicians were also exposed to cytotoxic agents detected in logistical and storage areas. Protective measures should therefore be maintained or even reinforced in these areas in order to limit technicians’ risks of exposure when handling cytotoxic products.