RT Journal Article SR Electronic T1 PP-007 Stability of diluted and reconstituted antineoplastic drugs: updated 2014 JF European Journal of Hospital Pharmacy JO Eur J Hosp Pharm FD British Medical Journal Publishing Group SP A119 OP A119 DO 10.1136/ejhpharm-2015-000639.287 VO 22 IS Suppl 1 A1 R Guerrero Bautista A1 E Ferris Villanueva A1 MR Gutiérrez Cívicos A1 MH García Lagunar A1 A García Márquez A1 I Muñoz García A1 M Martínez Penella YR 2015 UL http://ejhp.bmj.com/content/22/Suppl_1/A119.2.abstract AB Background The lack of studies published on stability of antineoplastic drugs and the contradictory character of the information available increased the need to carry out an internal review in our hospital.Purpose To investigate the physical-chemical stability of vials of antineoplastic drugs included in the hospital’s Therapeutic Prescription Guide after opening and/or reconstitution.Material and methods We reviewed all information available in the Spanish Medicines Agency Technical Data Sheets, Micromedex, Stabilis, papers on PubMed and updated guides published by other hospitals in order to establish the physical-chemical stability of these types of drugs.Results The following storage conditions and maximum storage times were found for 35 cytostatic drugs in use in the hospital: 24 months refrigerated (α 2-B interferon), 90 days at room temperature (RT) (cetuximab), 90 days refrigerated and protected from light (PL) (bevacizumab), 31 days refrigerated PL (pemetrexed), 30 days refrigerated and PL (methotrexate, rituximab, vinorelbine), 28 days at RT (eribulin, etoposide, paclitaxel), 28 days at RT and PL (cisplatin, docetaxel, fluorouracil), 28 days refrigerated (vinblastine), 28 days refrigerated and PL (doxorubicin, pegylated liposomal doxorubicin), 26 days at RT and PL (fludarabine), 22 days refrigerated (mitoxantrone), 21 days refrigerated and PL (carboplatin, ifosfamide), 14 days refrigerated and PL (cyclophosphamide, epirubicin, oxaliplatin, topotecan, mitomycin, vincristine), 8 days frozen with WFI (water for injection) (azacitidine), 7days at RT (carmustine, irinotecan), 7 days refrigerated (cytarabine), 7 days refrigerated and PL (dactinomycin, daunorubicin, gemcitabine, non-pegylated liposomal doxorubicin and idarubicin).Conclusion The storage protocol was modified for cytostatic vials that had been opened/reconstituted under aseptic conditions using a vertical laminar flow cabin depending on their maximum stabilities. The resulting document was thereafter incorporated into regular working practice. The updated protocol resulted in the medicines being used safely and significant savings on these costly drugs.References and/or acknowledgements Oncology DepartmentNo conflict of interest.