@article {G{\'o}mez Fern{\'a}ndezA111, author = {E G{\'o}mez Fern{\'a}ndez and R Jimenez Galan and Y Borrego Izquierdo and MR Cantudo Cuenca and F Orantes Casado de Amezua and M Robustillo Cortes and E Calvo Cidoncha and M Manzano Garcia and C Haro M{\'a}rquez and R Morillo Verdugo}, title = {DI-093 Predictors of non-adherence to highly active antiretroviral therapy in HIV-infected patients}, volume = {22}, number = {Suppl 1}, pages = {A111--A111}, year = {2015}, doi = {10.1136/ejhpharm-2015-000639.267}, publisher = {BMJ Specialist Journals}, abstract = {Background Highly active antiretroviral therapy (HAART) has significantly reduced morbidity and mortality, transforming HIV into a chronic disease. The increase in life expectancy in these patients has led to a higher prevalence of comorbidities and use of concomitant medicines, which may limit adherence and therapeutic success.Purpose To determine the prevalence of other chronic diseases in HIV-infected patients and to identify predictors of non-adherence to HAART.Material and methods Single-centre retrospective study that included HIV-infected patients on HAART who attended pharmaceutical care at a pharmacy service from January to December 2013. The dependent variable was non-adherence to HAART (patients were considered non-adherent to HAART if the percentage of adherence through dispensing records was <=90\%). The independent variables were: sex, age, number of chronic diseases and concomitant medicines, and the presence of specific diseases (viral liver disease, dyslipidaemia, central nervous system disease, cardiovascular disease or hypertension).Statistical analysis: to identify independent predictors of non-adherence, we performed a multivariate logistic regression analysis.Results A total of 598 patients were analysed. 78.9\% were men, mean age was 48 years (IQR: 42{\textendash}52). The average number of comorbidities per patient was 1.6 {\textpm} 1.4. 31.3\% of patients had viral liver disease, 17.9\% dyslipidaemia, 15.6\% central nervous system disease and 14.4\% cardiovascular disease or hypertension. The average number of concurrent drugs per patient was 1.9 {\textpm} 2.7. 85.3\% of patients were adherent to HAART. In the multivariate analysis, presence of viral liver disease was the only variable significantly associated with non-adherence to HAART (OR: 1.81); p = 0.02). The number of chronic diseases and concurrent drugs was not associated with non-adherence.Conclusion The prevalence of other chronic diseases in HIV-infected patients was high. The presence of viral liver disease was identified as a predictor of non-adherence in HIV-patients in this study.ReferenceGleason LJ, et al. Polypharmacy in the HIV-infected older adult population. Clin Interv Aging 2013;8:749{\textendash}63ReferenceNo conflict of interest.}, issn = {2047-9956}, URL = {https://ejhp.bmj.com/content/22/Suppl_1/A111.1}, eprint = {https://ejhp.bmj.com/content/22/Suppl_1/A111.1.full.pdf}, journal = {European Journal of Hospital Pharmacy} }